Impact of Simultaneous Versus Sequential Initiation of Basal Insulin and Glucagon-like Peptide-1 Receptor Agonists on HbA1c in Type 2 Diabetes: A Retrospective Observational Study
| العنوان: | Impact of Simultaneous Versus Sequential Initiation of Basal Insulin and Glucagon-like Peptide-1 Receptor Agonists on HbA1c in Type 2 Diabetes: A Retrospective Observational Study |
|---|---|
| المؤلفون: | Vivian Fonseca, Rajeev Ayyagari, Lizheng Shi, Priscilla Hollander, Xuejun Victor Peng, Eboni G. Price-Haywood, Robert Lubwama |
| المصدر: | Diabetes Therapy |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, HbA1c, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Type 2 diabetes mellitus, Internal Medicine, medicine, Basal insulin, Glucagon-like peptide 1 receptor, Glycemic, Real-world evidence, business.industry, Brief Report, Retrospective cohort study, medicine.disease, chemistry, Hyperglycemia, Cohort, Glucagon-like peptide-1 receptor agonist, Observational study, Glycated hemoglobin, business |
| الوصف: | Introduction When and how to intensify treatment in patients with type 2 diabetes (T2D) not achieving glycated hemoglobin (HbA1c) targets with oral antidiabetic drugs (OADs) in clinical practice remains a matter of clinical preference. This pilot study was conducted using the retrospective observational data from such patients to evaluate the impact on HbA1c of three treatment sequences: simultaneous initiation of basal insulin (BI) and a glucagon-like peptide-1 receptor agonist (GLP-1 RA; Cohort 1); BI followed by GLP-1 RA initiation within a 90-day timeframe (Cohort 2); or BI followed by GLP-1 RA initiation beyond 90 days (Cohort 3). Methods Data from the regional US electronic medical records database, Research Action for Health Network (REACHnet), were extracted for all patients with T2D aged ≥ 18 years who had encounter dates between January 2011 and August 2017 and ≥ 1 HbA1c laboratory value(s) |
| تدمد: | 1869-6961 1869-6953 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b033b1faafec924287935e9789d508f8Test https://doi.org/10.1007/s13300-020-00783-4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b033b1faafec924287935e9789d508f8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18696961 18696953 |
|---|