P03.05 Could suspected Glioblastomas be Treated without Hystological Diagnosis?
| العنوان: | P03.05 Could suspected Glioblastomas be Treated without Hystological Diagnosis? |
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| المؤلفون: | M. Molla Armada, F Graus Ribas, C. Castro Cuevas, G. Oses González, E. Verger Fransoy, L Pedrosa Eguílaz, T Pujol Farre, C Camacho López, A Lloret Puerto, K Cortés Mateus, T Barreto Zambrano, D Muñoz Guglielmetti, E Pineda Losada, L Oleaga Zufiria, J González Sánchez, I. Valduvieco Ruiz, C. Conill Llobet, S Garrido Alcantud, J. Sáez Beltrán, E. Escudero López |
| المصدر: | Neuro Oncol |
| بيانات النشر: | Oxford University Press (OUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Karnofsky Performance Status, medicine.diagnostic_test, business.industry, medicine.disease, Comorbidity, Poster Presentations, Oncology, Biopsy, Medical imaging, medicine, Neurology (clinical), Radiology, Liquid biopsy, business, Glioblastoma |
| الوصف: | BACKGROUND Probable unresectable Glioblastomas (GB) diagnosed by imaging techniques withouth anatomo-pathological (ap) confirmation could be treated under standard treatment. We reported the outcomes from this strategy in our center after tumor board evaluation. MATERIAL AND METHODS From January/10 to September/16, 303 patients (pt) with GB were assessed by tumor board, during the same period 66 patients were consecutive analyzed with suspected GB by radiological criteria without histological diagnosis. We focus in the last group and analyzed the demographic/radiological data, non-biopsy causes, treatment type (concomitant Radio-Chemotherapy (RT/Ch), exclusive RT or Ch or Best supportive care (BSC)), Karnofsky index (KI) and degree of comorbidity (Charlson index (CI)). RESULTS Sixty six patients, 17.88% of the total GB cases (with/without ap). Average age: 77 years (33–91). Biopsy: non-diagnostic in 4pt. No biopsy: 62pt; due to non medical indication (71%), localization (22.7%), voluntary (4.5%). Treatment Type: Active: 43.93%, without biopsy due to non-medical indication (44.8%) and localization (41.37%). BSC: 53.03%, without biopsy due to non-medical indication 82.85%, localization 8.5%, voluntary 5.7%. Overall survival: 11.65 months in patients with active treatment and 4.8 months in BSC, greater benefit in CONCLUSION The diagnosis of GB by radiological criteria with the new imaging techniques has a good diagnostic-therapeutic correlation. In cases where surgical intervention is not possible, standard treatment offers good results. Age and KPS are variables that allow predicting a better evolution course. Although it was not possible to obtain a histological diagnosis, in this type of cases liquid biopsy could contribute to diagnosis this type of lesions inaccessible to biopsy. |
| تدمد: | 1523-5866 1522-8517 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affc2ff48ade0b2c32ad6d03ecb146dfTest https://doi.org/10.1093/neuonc/noz126.086Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....affc2ff48ade0b2c32ad6d03ecb146df |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15235866 15228517 |
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