The mitochondrial death pathway: a promising therapeutic target in diseases
| العنوان: | The mitochondrial death pathway: a promising therapeutic target in diseases |
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| المؤلفون: | Sanjeev Gupta, George E.N. Kass, Eva Szegezdi, Bertrand Joseph |
| المصدر: | Journal of Cellular and Molecular Medicine |
| بيانات النشر: | Wiley, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Mitochondrial Diseases, bcl-2, amyotrophic-lateral-sclerosis, Reviews, Cellular homeostasis, Mitochondrion, Biology, Models, Biological, Mitochondrial apoptosis-induced channel, cytochrome-c release, peripheral benzodiazepine-receptor, apoptosis-inducing factor, etoposide-induced apoptosis, Animals, Humans, bcl-2 family-members, adenine-nucleotide translocator, bcl-2-Associated X Protein, mitochondrial outer membrane permeabilization, programmed cell-death, Membrane Potential, Mitochondrial, permeability transition pore, Bcl-2 family, apoptosis, Cell Biology, Mitochondria, Cell biology, Proto-Oncogene Proteins c-bcl-2, caspases, electron-transport chain, mitochondrial fusion, Mitochondrial permeability transition pore, DNAJA3, Molecular Medicine, Apoptosome, Signal Transduction, mitochondrial permeability transition |
| الوصف: | The mitochondrial pathway to apoptosis is a major pathway of physiological cell death in vertebrates. The mitochondrial cell death pathway commences when apoptogenic molecules present between the outer and inner mitochondrial membranes are released into the cytosol by mitochondrial outer membrane permeabilization ( MOMP). BCL-2 family members are the sentinels of MOMP in the mitochondrial apoptotic pathway; the pro-apoptotic B cell lymphoma (BCL)-2 proteins, BCL-2 associated x protein and BCL-2 antagonist killer 1 induce MOMP whereas the anti-apoptotic BCL-2 proteins, BCL-2, BCL-x(L) and myeloid cell leukaemia 1 prevent MOMP from occurring. The release of pro-apoptotic factors such as cytochrome c from mitochondria leads to formation of a multimeric complex known as the apoptosome and initiates caspase activation cascades. These pathways are important for normal cellular homeostasis and play key roles in the pathogenesis of many diseases. In this review, we will provide a brief overview of the mitochondrial death pathway and focus on a selection of diseases whose pathogenesis involves the mitochondrial death pathway and we will examine the various pharmacological approaches that target this pathway. |
| تدمد: | 1582-4934 1582-1838 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec68702ae94c60ab920038189210eb7Test https://doi.org/10.1111/j.1582-4934.2009.00697.xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....aec68702ae94c60ab920038189210eb7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15824934 15821838 |
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