Thyroid Sequelae of Pediatric Cancer Therapy
| العنوان: | Thyroid Sequelae of Pediatric Cancer Therapy |
|---|---|
| المؤلفون: | Steven G. Waguespack |
| المصدر: | Hormone Research in Paediatrics. 91:104-117 |
| بيانات النشر: | S. Karger AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, Oncology, endocrine system, medicine.medical_specialty, Adolescent, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Thyroid Gland, 030209 endocrinology & metabolism, Disease, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Cancer Survivors, Internal medicine, Humans, Medicine, Thyroid Neoplasms, Child, Adverse effect, Protein Kinase Inhibitors, Thyroid cancer, 030219 obstetrics & reproductive medicine, business.industry, Thyroid disease, Thyroid, Late effect, Infant, Cancer, Neoplasms, Second Primary, medicine.disease, Pediatric cancer, medicine.anatomical_structure, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, Radiopharmaceuticals, medicine.symptom, business |
| الوصف: | The hypothalamic-pituitary-thyroid axis is a common site of unintended, acquired disease either during or after the treatment of cancer. Children treated with external radiation therapy are at the highest risk for developing a thyroid-related late effect, but thyroid dysfunction and second primary thyroid neoplasms can also occur after treatment with radiopharmaceutical agents such as 131I-metaiodobenzylguanidine. Increasingly recognized is the development of early thyroid dysfunction as an off-target consequence of the more novel cancer therapeutics such as the tyrosine kinase inhibitors and immune checkpoint inhibitors. Thyroid sequelae resulting from irradiation may manifest only after years to decades of follow-up, and their resultant clinical symptoms may be indolent and non-specific. Therefore, lifelong monitoring of the childhood cancer survivor at risk for thyroid disease is paramount. In this comprehensive review, the myriad thyroid adverse effects resulting from pediatric cancer treatment are discussed and an overview of screening and treatment of these thyroid sequelae provided. |
| تدمد: | 1663-2826 1663-2818 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7e4e2b46fef1afb932fbfe26cdcbc7Test https://doi.org/10.1159/000495040Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ae7e4e2b46fef1afb932fbfe26cdcbc7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16632826 16632818 |
|---|