Structure and thermodynamical properties of metformin salicylate
| العنوان: | Structure and thermodynamical properties of metformin salicylate |
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| المؤلفون: | Laura Menéndez-Taboada, Nieves Fresno, Pilar Goya, Carlos Marco, José Elguero, Santiago García-Granda, Ruth Pérez-Fernández |
| المساهمون: | Factoría Española de Cristalización, Ministerio de Economía y Competitividad (España), European Commission |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | American Chemical Society, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Hydrogen bond, Salt (chemistry), General Chemistry, Condensed Matter Physics, Cocrystal, Metformin, Ion, chemistry.chemical_compound, Crystallography, chemistry, Intramolecular force, medicine, Organic chemistry, General Materials Science, Powder diffraction, Salicylic acid, medicine.drug |
| الوصف: | The behavior under thermal conditions of the cocrystal formed by metformin and salicylic acid was studied by DSC, crystallography (single-crystal), and powder diffraction (WAXS). Metformin salicylate crystallizes in space group P21/c, with the salicylate anion showing a planar structure, stabilized by strong intramolecular hydrogen bonds. The more flexible metformin cations link through the oxygen atoms of salicylate, forming a dense hydrogen-bonding network. The compound exists initially as a salt, metformin salicylate, but after melting and cooling, it is transformed into a glass form that crystallizes and melts again, showing different behaviors depending on the heating rate. © 2013 American Chemical Society. This work was supported by SAF2009-12422-C02-02 and RTA (RED Trastornos Adictivos RD06/001/0014) as well as by FEDER funding and the Spanish Ministerio de Economía y Competitividad MAT2006-01997, MAT2010-15094, and the Factoría de Crystalización (Consolider Ingenio 2010). |
| اللغة: | English |
| تدمد: | 1528-7505 1528-7483 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae330efa1ae09c67ab49534778f0fa0eTest http://hdl.handle.net/10261/83000Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ae330efa1ae09c67ab49534778f0fa0e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15287505 15287483 |
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