Chronic stress affects the expression of brain-derived neurotrophic factor in rat salivary glands
| العنوان: | Chronic stress affects the expression of brain-derived neurotrophic factor in rat salivary glands |
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| المؤلفون: | Takeshi Takahashi, Juri Saruta, Keiichi Tsukinoki, Sadao Sato, Chikatoshi Sato, Taeki Lee, Masayoshi Shirasu |
| المصدر: | Stress. 13:53-60 |
| بيانات النشر: | Informa UK Limited, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, Restraint, Physical, Hypothalamo-Hypophyseal System, medicine.medical_specialty, Physiology, Submandibular Gland, Radioimmunoassay, Pituitary-Adrenal System, Adrenocorticotropic hormone, Rats, Sprague-Dawley, Behavioral Neuroscience, chemistry.chemical_compound, Adrenocorticotropic Hormone, stomatognathic system, Stress, Physiological, Corticosterone, Neurotrophic factors, Internal medicine, medicine, Animals, Chronic stress, RNA, Messenger, Brain-derived neurotrophic factor, Analysis of Variance, Messenger RNA, Reverse Transcriptase Polymerase Chain Reaction, Endocrine and Autonomic Systems, business.industry, Brain-Derived Neurotrophic Factor, Immunohistochemistry, Submandibular gland, Rats, Psychiatry and Mental health, Neuropsychology and Physiological Psychology, Endocrinology, medicine.anatomical_structure, nervous system, chemistry, Chronic Disease, business, Homeostasis |
| الوصف: | Plasma brain-derived neurotrophic factor (BDNF) levels are associated with several neural disorders. Previously, we reported that BDNF is produced from salivary glands under acute immobilization stress. Additionally, salivary glands are the origin of plasma BDNF during stress; however, the association between the expression of BDNF by the salivary glands under chronic stress conditions is not known. In the present study, we investigated whether plasma BDNF levels in chronic stress depend on the salivary glands. Expression of BDNF mRNA and protein were identified in the submandibular glands when male rats were exposed to chronic restraint stress (12 h daily for 22 days). Chronic stress significantly increased plasma BDNF concentration, as well as adrenocorticotropic hormone and corticosterone levels, but was not altered under chronic stress in bilaterally sialoadenectomized rats. Since chronic stress increases plasma BDNF levels in the sialoadenectomized rat model, the plasma BDNF level was not dependent on BDNF from the salivary glands. Although the salivary glands were the source of plasma BDNF in acute stress conditions in our previous study, it seems that that the increased BDNF expression in the salivary glands in chronic stress does not contribute importantly to the increased circulating BDNF level. The increased plasma BDNF levels may play important roles in homeostasis under stress conditions. |
| تدمد: | 1607-8888 1025-3890 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adeb70b2510bc5d0868f7cf23484b577Test https://doi.org/10.3109/10253890902875167Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....adeb70b2510bc5d0868f7cf23484b577 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16078888 10253890 |
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