Relationships between early age at onset of psychotic symptoms and treatment resistant schizophrenia
| العنوان: | Relationships between early age at onset of psychotic symptoms and treatment resistant schizophrenia |
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| المؤلفون: | Luigi D’Ambrosio, Michele Fornaro, Eugenio Razzino, Camilla Avagliano, Danilo Notar Francesco, Marta Matrone, Federica Milandri, Annarita Barone, Andrea de Bartolomeis, Felice Iasevoli, Benedetta Altavilla, Mariateresa Ciccarelli |
| المساهمون: | Iasevoli, F., Razzino, E., Altavilla, B., Avagliano, C., Barone, A., Ciccarelli, M., D'Ambrosio, L., Matrone, M., Milandri, F., Notar Francesco, D., Fornaro, M., de Bartolomeis, A. |
| المصدر: | Early Intervention in Psychiatry. 16:352-362 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, endocrine system, Psychosis, medicine.medical_specialty, animal structures, Adolescent, medicine.medical_treatment, psychosi, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Prospective Studies, Age of Onset, Antipsychotic, Biological Psychiatry, Clozapine, Analysis of covariance, clozapine, business.industry, medicine.disease, antipsychotic, 030227 psychiatry, refractory, Psychiatry and Mental health, Schizophrenia, Schizophrenic Psychology, Analysis of variance, Pshychiatric Mental Health, Age of onset, business, Psychosocial, Schizophrenia, Treatment-Resistant, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery, Antipsychotic Agents, medicine.drug |
| الوصف: | Aim Early age at schizophrenia onset (EOS) has been associated with a worse clinical course, although previous studies reported substantial heterogeneity. Despite the relevance of the subject, the relationship between the age of onset and treatment resistant schizophrenia (TRS) is less clear. Methods We screened 197 non-affective psychotic patients. Of these, 99 suffered from schizophrenia and were putative TRS and were included in a prospective 4-to-8-week trial to assess their response to antipsychotics. According to status (TRS/nonTRS) and age-at-onset (early: ≤18 years, EOS; adult: >18 years, adult onset schizophrenia [AOS]) patients were subdivided in EOS-TRS, EOS-nonTRS, AOS-TRS, AOS-nonTRS. Multiple clinical variables were measured and compared by analysis of covariance (ANCOVA), using age as a covariate. Two-way analysis of variance (ANOVA) was used to assess whether significant differences were attributable to TRS status or age-at-onset. Results The rate of TRS patients was significantly higher in EOS compared to AOS. At the ANCOVA, EOS-TRS had significantly worse clinical, cognitive, and psychosocial outcomes compared to the other groups. Overall, EOS-TRS were more impaired than EOS-nonTRS, while significant differences with AOS-TRS were less consistent, albeit appreciable. Two-way ANOVA demonstrated that, in the majority of the investigated variables, the significant differences among groups were attributable to the TRS status effect rather than to age-at-onset or combined effects. Conclusions These results suggest that refractoriness to antipsychotics may be strongly linked to the early onset of psychotic symptoms, possibly as a result of common neurobiology. |
| تدمد: | 1751-7893 1751-7885 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::accf69274b8a03b09323523e3ac9ca62Test https://doi.org/10.1111/eip.13174Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....accf69274b8a03b09323523e3ac9ca62 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17517893 17517885 |
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