Efficient Photodynamic Killing of Gram-Positive Bacteria by Synthetic Curcuminoids
| العنوان: | Efficient Photodynamic Killing of Gram-Positive Bacteria by Synthetic Curcuminoids |
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| المؤلفون: | Anren Hu, Chia-Jou Kuo, Yi-Wen Hua, Kai-Yu Lin, Yi-An Hong, Tzenge-Lien Shih, Hao-Ping Chen, Sung-Jen Hung |
| المصدر: | International Journal of Molecular Sciences Volume 21 Issue 23 International Journal of Molecular Sciences, Vol 21, Iss 9024, p 9024 (2020) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Staphylococcus aureus, Light, Aerobic bacteria, Gram-positive bacteria, demethoxycurcumin, Microbial Sensitivity Tests, 010402 general chemistry, Gram-Positive Bacteria, 01 natural sciences, Staphylococcus epidermis, Catalysis, Article, Microbiology, photodynamic inactivation, Inorganic Chemistry, lcsh:Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Propionibacterium acnes, 0302 clinical medicine, Staphylococcus epidermidis, Diarylheptanoids, Bisdemethoxycurcumin, curcumin, Curcuminoid, Physical and Theoretical Chemistry, Molecular Biology, lcsh:QH301-705.5, Spectroscopy, Microbial Viability, biology, Organic Chemistry, Cell Membrane, bisdemethoxycurcumin, General Medicine, biology.organism_classification, 0104 chemical sciences, Computer Science Applications, chemistry, lcsh:Biology (General), lcsh:QD1-999, Photochemotherapy, Curcumin, curcuminoid, Antibacterial activity, 030215 immunology |
| الوصف: | In our previous study, we have demonstrated that curcumin can efficiently kill the anaerobic bacterium Propionibacterium acnes by irradiation with low-dose blue light. The curcuminoids present in natural plant turmeric mainly include curcumin, demethoxycurcumin, and bisdemethoxycurcumin. However, only curcumin is commercially available. Eighteen different curcumin analogs, including demethoxycurcumin and bisdemethoxycurcumin, were synthesized in this study. Their antibacterial activity against Gram-positive aerobic bacteria Staphylococcus aureus and Staphylococcus epidermidis was investigated using the photodynamic inactivation method. Among the three compounds in turmeric, curcumin activity is the weakest, and bisdemethoxycurcumin possesses the strongest activity. However, two synthetic compounds, (1E,6E)-1,7-bis(4-bromophenyl)hepta-1,6-diene-3,5-dione and (1E,6E)-1,7-bis(3-bromophenyl)hepta -1,6-diene-3,5-dione, possess the best antibacterial activity among all compounds examined in this study. Their chemical stability is also better than that of bisdemethoxycurcumin, and thus has potential for future clinical applications. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| DOI: | 10.3390/ijms21239024 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca0c5795ebc1f6d755638eb96a48a71Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....aca0c5795ebc1f6d755638eb96a48a71 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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| DOI: | 10.3390/ijms21239024 |