Phosphoinositide-3-Kinase-Dependent, MyD88-Independent Induction of CC-Type Chemokines Characterizes the Macrophage Response toToxoplasma gondiiStrains with High Virulence
| العنوان: | Phosphoinositide-3-Kinase-Dependent, MyD88-Independent Induction of CC-Type Chemokines Characterizes the Macrophage Response toToxoplasma gondiiStrains with High Virulence |
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| المؤلفون: | Eric Y. Denkers, Woraporn Sukhumavasi, Chiang W. Lee |
| المصدر: | Infection and Immunity. 75:5788-5797 |
| بيانات النشر: | American Society for Microbiology, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Chemokine, Immunology, Virulence, Inflammation, CCL7, Microbiology, Proinflammatory cytokine, Mice, Phosphatidylinositol 3-Kinases, medicine, Animals, biology, Gene Expression Profiling, Macrophages, Toxoplasma gondii, Acquired immune system, biology.organism_classification, Mice, Inbred C57BL, Infectious Diseases, Chemokines, CC, Myeloid Differentiation Factor 88, biology.protein, Female, Parasitology, Chemokine CCL17, Fungal and Parasitic Infections, medicine.symptom, Signal transduction, Toxoplasma, Toxoplasmosis, Signal Transduction |
| الوصف: | Chemokines play an important role in inflammation and infection due to their ability to recruit cells of innate and adaptive immunity. Here we examined mouse macrophage chemokine responses during intracellular infections with high- and low-virulenceToxoplasma gondiistrains. The high-virulence type I strain RH induced a large panel of CC-type chemokines, whereas responses elicited by strains PTG (type II) and M7741 (type III) were much weaker. Strikingly, theT. gondii-induced chemokine response occurred independently of signaling through the Toll-like receptor adaptor MyD88. Instead, production of chemokines during infection was heavily dependent upon phosphoinositide-3-kinase signaling pathways. Because infection with type I strains such as RH results in an uncontrolled proinflammatory cytokine response, we hypothesize that this virulence phenotype is a consequence of early strong induction of chemokines by type I, but not type II or III,Toxoplasmastrains. |
| تدمد: | 1098-5522 0019-9567 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac497fe4af105cdd1d3a52d3f4335f13Test https://doi.org/10.1128/iai.00821-07Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ac497fe4af105cdd1d3a52d3f4335f13 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10985522 00199567 |
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