Overall survival and clinical characteristics of BRCA mutation carriers with stage I/II pancreatic cancer
| العنوان: | Overall survival and clinical characteristics of BRCA mutation carriers with stage I/II pancreatic cancer |
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| المؤلفون: | Milind Javle, Talia Golan, Eitan Friedmen, David P. Kelsen, Tal Sella, Matthew H.G. Katz, Ayelet Borgida, Steven Gallinger, Hannah Maynard, Ron Epelbaum, Eileen M. O'Reilly, Hedy L. Kindler |
| المصدر: | British Journal of Cancer |
| بيانات النشر: | Nature Publishing Group, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Male, Cancer Research, endocrine system diseases, medicine.medical_treatment, pancreatic cancer, DFS, 0302 clinical medicine, Antineoplastic Combined Chemotherapy Protocols, skin and connective tissue diseases, Neoadjuvant therapy, education.field_of_study, BRCA1 Protein, OS, Middle Aged, Prognosis, Neoadjuvant Therapy, Survival Rate, Exact test, 030220 oncology & carcinogenesis, Adenocarcinoma, Female, Adult, medicine.medical_specialty, Heterozygote, Population, Biology, 03 medical and health sciences, BRCA 1, Internal medicine, Pancreatic cancer, medicine, Adjuvant therapy, Humans, Neoplasm Invasiveness, education, Survival rate, Germ-Line Mutation, Aged, Neoplasm Staging, Retrospective Studies, BRCA2 Protein, BRCA mutation, case–control study, medicine.disease, BRCA2, Pancreatic Neoplasms, 030104 developmental biology, Case-Control Studies, Clinical Study, Neoplasm Grading, Neoplasm Recurrence, Local, Follow-Up Studies |
| الوصف: | Background: BRCA1/BRCA2 germ line (GL) mutation carriers with pancreatic adenocarcinoma (PDAC) may have distinct outcomes. We recently described an apparent more favourable prognosis of surgically resected BRCA-associated PDAC patients in a single-arm, uncontrolled, retrospective study. However, the prognostic impact of GL BRCA1/2 mutations in surgically resected PDAC has not been compared with a matched control population. Methods: A larger multi-centre, case–control retrospective analysis was performed. Cases were patients with surgically resected, BRCA1/2-associated PDAC from 2004 to 2013. Controls included surgically resected PDAC cases treated during the same time period that were either BRCA non-carriers, or had no family history of breast, ovarian or pancreatic cancers. Cases and controls were matched by: age at diagnosis (within ±5-year period) and institution. Demographics, clinical history, overall survival (OS) and disease-free survival (DFS) were abstracted from patient records. Statistical comparisons were assessed using χ2- and Fisher's exact test, and median DFS/OS using Kaplan–Meier method and log-rank testing. Results: Twenty-five patients with BRCA1-(n=4) or BRCA2 (N=21)-associated resectable PDAC were identified. Mean age was 55.7 years (range, 34–78 years), 48% (n=12) were females and 76% (n=19) were Jewish. Cases were compared (1 : 2) with 49 resectable PDAC controls, and were balanced for age, ethnicity and other relevant clinical and pathological features. BRCA-associated PDAC patients received neoadjuvant, or adjuvant platinum-based treatment more frequently than controls (7 out of 8 vs 6 out of 14) and (7 out of 21 vs 3 out of 44), respectively. No significant difference in median OS (37.06 vs 38.77 months, P=0.838) and in DFS (14.3 vs 12.0 months, P=0.303) could be demonstrated between cases and controls. A trend to increased DFS was observed among BRCA-positive cases treated with neoadjuvant/adjuvant platinum-containing regimens (n=10) compared with similarly treated controls (n=7) (39.1 vs 12.4 months, P=0.255). Conclusions: In this retrospective analysis, the prognosis of surgically resectable BRCA-associated PDAC is no different than that of sporadic PDAC from the same institution. The role of platinum-based adjuvant therapy in this setting requires prospective investigation. |
| اللغة: | English |
| تدمد: | 1532-1827 0007-0920 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac11f764505f39bc5416cd368d44420aTest http://europepmc.org/articles/PMC5355924Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ac11f764505f39bc5416cd368d44420a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00070920 |
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