Insulin Gene Profile Cycles with Season of Birth of Future Diabetic Children and their Relatives
| العنوان: | Insulin Gene Profile Cycles with Season of Birth of Future Diabetic Children and their Relatives |
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| المؤلفون: | D. Michalková, P. Minárik, M. Mikulecky |
| المصدر: | Journal of Pediatric Endocrinology and Metabolism. 17 |
| بيانات النشر: | Walter de Gruyter GmbH, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Genetic Markers, Risk, Slovakia, Season of birth, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Endocrinology, Predictive Value of Tests, Reference Values, medicine, Humans, Insulin, Genetic Predisposition to Disease, Allele, Child, Genotyping, Insulin Gene, Type 1 diabetes, Framingham Risk Score, business.industry, Infant, medicine.disease, Diabetes Mellitus, Type 1, Child, Preschool, Pediatrics, Perinatology and Child Health, Seasons, business, Demography |
| الوصف: | Background: HLA class II gene pattern and IA-2A antibody positivity, revealing selected risks for prediction of type 1 diabetes mellitus (DM1), were previously shown to be cycling roughly in parallel with seasonally fluctuating frequencies of births of future diabetic children. Is this also true for insulin genotyping? Is this also true for births of the healthy close relatives of children with DM1? Patients and Methods: In 98 Slovak children with DM1 and in 60 healthy parents and siblings, two single nucleotide polymorphisms of the insulin gene (-23 Hph I; +1127 Pst I) were typed. Results were expressed as score 0 (maximal risk) up to 2 (minimal risk or protection), or 0-4 for the sum of both scores. Birth seasonality of these risk scores was tested by Halberg cosinor regression. Results: Results were similar for the two alleles; therefore, the summed risk score was evaluated. The DM1 risk from the insulin gene pattern in births of future diabetics cycled significantly semi-annually, with maxima around the spring and autumn equinoxes. In the relatives, a significant annual and extremely pronounced quarterly peaking rhythm was found, with maximum risk in births around the autumn equinox and shortly after the winter solstice. Significant protection peaks are present in late winter, spring and summer. Conclusion: The highest frequency of Coxsackie infections in the Slovakian child population, and of 'diabetic' births and manifestations, found earlier together with maximal risks from HLA II and IA-2A antibodies in late summer and early autumn, is now confirmed also for the insulin gene pattern in diabetic children and even also for their healthy close relatives. |
| تدمد: | 2191-0251 0334-018X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6f837291d614583772342116ed2ce1Test https://doi.org/10.1515/jpem.2004.17.5.727Test |
| رقم الانضمام: | edsair.doi.dedup.....ab6f837291d614583772342116ed2ce1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21910251 0334018X |
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