Sodium Intake Is associated With Endothelial Damage Biomarkers and Metabolic Dysregulation
| العنوان: | Sodium Intake Is associated With Endothelial Damage Biomarkers and Metabolic Dysregulation |
|---|---|
| المؤلفون: | Doris Muñoz, Andrea Vecchiola, Cristobal A. Fuentes, Alejandro Martinez-Aguayo, Alejandra Tapia-Castillo, Sandra Solari, Lorena García, María Paulina Rojas, Cristian A. Carvajal, Rene Baudrand, Fidel Allende, Carmen Campino, Carolina A Valdivia, Carlos F. Lagos, Carlos E. Fardella, Hernán García |
| المصدر: | American Journal Of Hypertension Artículos CONICYT CONICYT Chile instacron:CONICYT |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Blood Glucose, medicine.medical_specialty, Adolescent, Urinary system, Sodium, chemistry.chemical_element, Blood Pressure, 030204 cardiovascular system & hematology, Recommended Dietary Allowances, Plasma renin activity, Excretion, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, Risk Factors, Internal medicine, Plasminogen Activator Inhibitor 1, Internal Medicine, Medicine, Humans, 030212 general & internal medicine, Chile, Child, Aged, Creatinine, Aldosterone, Adiponectin, business.industry, Sodium, Dietary, Middle Aged, Lipids, Oxidative Stress, Renal Elimination, Blood pressure, Endocrinology, Cross-Sectional Studies, chemistry, Cardiovascular Diseases, Endothelium, Vascular, Inflammation Mediators, business, Energy Metabolism, Biomarkers |
| الوصف: | BACKGROUND Mounting evidence has associated high sodium (HS) intake with hypertension, cardiovascular disease, and stroke. We investigated whether HS intake modulates the parameters of endothelial damage, inflammation, and oxidative stress. METHODS We used a cross-sectional study design including 223 Chilean subjects (6.9–65.0 years old). We measured aldosterone, renin activity, cortisol, cortisone, adiponectin, leptin, hsCRP, interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), plasminogen activator inhibitor type 1 (PAI-1), metalloproteinase (MMP)-9 and MMP-2 activity, and malondialdehyde. Sodium and creatinine were measured in 24-hour urine samples. The subjects were divided by sodium intake, high sodium (HS): ≥150 mEq/day, n = 118, and adequate sodium (AS): RESULTS We observed a positive correlation between urinary sodium excretion and blood pressure (r = 0.1669, P = 0.0124 for systolic and r = 0.2416, P = 0.0003 for diastolic), glycemia (r = 0.2660, P < 0.0001), and triglycerides (r = 0.1604, P = 0.0175) and a highly significant correlation between sodium excretion and PAI-1 (r = 0.2701, P < 0.0001). An inverse correlation was observed between urinary sodium and HDL-cholesterol (r = −0.2093, P = 0.0018) and adiponectin (r = −0.2679, P < 0.0001). In a linear regression model, urinary sodium excretion remained significantly associated with PAI-1 values even after adjusting for age, gender, and BMI. The HS group had higher blood pressure, glycemia, HOMA-IR, atherogenic index of plasma, and PAI-1 values than the group with AS intake. CONCLUSIONS HS intake is associated with endothelial damage (high PAI-1) and metabolic dysregulation. On the other hand, inflammation and oxidative stress parameters are not modified by sodium intake. |
| تدمد: | 1941-7225 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafd4d0323e3dd69ca4ab23d06fb32c0Test https://pubmed.ncbi.nlm.nih.gov/30289431Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....aafd4d0323e3dd69ca4ab23d06fb32c0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19417225 |
|---|