التفاصيل البيبلوغرافية
العنوان:
Regulation of stress signaling pathways by protein lipoxidation
المؤلفون:
Anna-Liisa Levonen , Carlos Cruz Cortés , Tommi Patinen , Jouni Härkönen , Ashik Jawahar Deen , Simone Adinolfi
المصدر:
Redox Biology, Vol 23, Iss, Pp-(2019)
بيانات النشر:
Elsevier, 2019.
سنة النشر:
2019
مصطلحات موضوعية:
RES, Reactive electrophilic species , ARE, Antioxidant response element , Biochemistry , Lipid peroxidation , 0302 clinical medicine , Heat Shock Transcription Factors , HSR, Heat shock response , lcsh:QH301-705.5 , Protein lipoxidation , SILAC, Stable isotope labeling with amino acids in cell culture , chemistry.chemical_classification , CUL3, (Cullin-3)-ubiquitin E3 ligase complex , Kelch-Like ECH-Associated Protein 1 , PGA2, Prostaglandin A2 , NTR, N-terminal region , CTD, C-terminal domain , RD, Regulatory domain , Cell biology , NO2-CLA, nitro-conjugated linoleic acid , KEAP1, Kelch-like ECH-associated protein 1 , OA-NO2, Nitro-oleic acid , lcsh:Medicine (General) , NF-E2-Related Factor 2 , 4-HNE, 4-hydroxy-2-nonenal , NRF2 , LNO2, 9-, 10-, 12-, or 13-nitro-octadeca-9, 12-dienoic acid , 03 medical and health sciences , Humans , NTD, N-terminal domain , PARP13, Poly(ADP-ribose) Polymerase 13 , Heat shock , LDE, Lipid-derived electrophiles , MS, Mass spectrometry , GCLC, Glutamate cysteine ligase catalytic , POLK, DNA polymerase kappa , Heat shock proteins , SH, sulfhydryl group , T-REX, Targetable reactive electrophiles and oxidants , DMSO, Dimethyl sulfoxide , 15d-PGJ2, 15-deoxy-Δ-12,14-prostaglandin J2 , SQSTM1, Autophagosome cargo protein Sequestosome 1 , KEAP1 , 030104 developmental biology , HSP90, 90-kDa heat shock proteins from HSP90 family , chemistry , Redox regulation , Lipid Peroxidation , Biomarkers , 030217 neurology & neurosurgery , PEIPC, 1-palmitoyl-2-(5, 6)-epoxy isoprostane E2)-sn-glycero-3-phosphocholine , ROS, Reactive oxygen species , LC-MS, Liquid chromatography-mass spectrometry , 0301 basic medicine , Cysteine modification , Clinical Biochemistry , H2O2, Hydrogen peroxide , IA, Iodoacetamide alkyne , PARP1, Poly(ADP-ribose) polymerase 1 , chemistry.chemical_compound , HSPD1/E1, Heat shock protein family D/E (Hsp60/Hsp10) member 1 , LOX12/15, 12/15-Lipoxygenase , HSF1 , HSPA8, Heat shock protein family A (Hsp70) member 8 , Ub, ubiquitin , lcsh:R5-920 , IER5, Immediate early response 5 , HSP, Heat shock protein , NQO1, NAD(P)H:quione oxidoreductase 1 , HSP40, 40-kDa heat shock proteins from HSP40 family , LZ4, Leucine zipper 4 domain , sMAF, small musculoaponeurotic fibrosarcoma oncogene homolog protein family , TEV, Tobacco etch virus , HSE, Heat shock element , GST, Gluthathione S-transferase , Second messenger system , Signal transduction , Oxidation-Reduction , Signal Transduction , CTAD, C-terminal transactivation domain , MD, Middle domain , ZAK, Animal-specific MAP kinase found in stress responses , Stress, Physiological , Implications of lipoxidation in cellular defense and stress pathway , Heat shock protein , GCLM, Glutamate-Cysteine Ligase Modifier Subunit , Animals , aLA, Alkyne-labeled linoleic acid , oxPAPC, Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine , Cysteine , ABPP, Affinity based protein profiling , IVR, Intervening region , Stress response , PRDX1, Peroxiredoxin 1 , Organic Chemistry , Neh, Nrf2-ECH homology , HSF1, Heat shock factor 1 , NRF2, NF-E2-related factor 2 , Oxidative Stress , BTB, Broad complex, Tram-track, and Bric-a-Brac , Enzyme , lcsh:Biology (General) , DBD, DNA binding domain , TXNR1D1, Thioredoxin reductase 1 , LZ1–3, Leucine zipper 1–3 domains , HSP70, 70-kDa heat shock proteins from HSP70 family , G-REX, Genome-wide variant of T-REX , MRP, Multidrug-resistance-associated protein
الوصف:
Enzymatic and non-enzymatic oxidation of unsaturated fatty acids gives rise to reactive species that covalently modify nucleophilic residues within redox sensitive protein sensors in a process called lipoxidation. This triggers adaptive signaling pathways that ultimately lead to increased resistance to stress. In this graphical review, we will provide an overview of pathways affected by protein lipoxidation and the key signaling proteins being altered, focusing on the KEAP1-NRF2 and heat shock response pathways. We review the mechanisms by which lipid peroxidation products can serve as second messengers and evoke cellular responses via covalent modification of key sensors of altered cellular environment, ultimately leading to adaptation to stress.
اللغة:
English
تدمد:
2213-2317
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafcf94c34748fdbf80fa6cb081441fcTest http://www.sciencedirect.com/science/article/pii/S221323171831067XTest
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....aafcf94c34748fdbf80fa6cb081441fc
قاعدة البيانات:
OpenAIRE
