Suppressed MKP-1 Is an Independent Predictor of Outcome in Patients with Hepatocellular Carcinoma
| العنوان: | Suppressed MKP-1 Is an Independent Predictor of Outcome in Patients with Hepatocellular Carcinoma |
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| المؤلفون: | Kazuya Endo, Yohsuke Kuroda, Akinobu Taketomi, Akihiro Watanabe, Shunji Kohnoe, Tomonobu Gion, Shinichi Aishima, Yoshihiko Maehara, Eiji Tsujita, Hideaki Nakashima |
| المصدر: | Oncology. 69:342-347 |
| بيانات النشر: | S. Karger AG, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, medicine.medical_specialty, Carcinoma, Hepatocellular, Down-Regulation, Cell Cycle Proteins, macromolecular substances, Disease-Free Survival, Gene Expression Regulation, Enzymologic, Immediate-Early Proteins, Downregulation and upregulation, Predictive Value of Tests, In vivo, Protein Phosphatase 1, Internal medicine, Biomarkers, Tumor, Phosphoprotein Phosphatases, Carcinoma, Humans, Medicine, Aged, Tumor marker, Aged, 80 and over, biology, Kinase, business.industry, Liver Neoplasms, Dual Specificity Phosphatase 1, General Medicine, Middle Aged, Prognosis, medicine.disease, Immunohistochemistry, Survival Analysis, Gene Expression Regulation, Neoplastic, Endocrinology, Oncology, Hepatocellular carcinoma, Mitogen-activated protein kinase, Cancer research, biology.protein, Female, alpha-Fetoproteins, Protein Tyrosine Phosphatases, business |
| الوصف: | Objective: An increase in the activity of mitogen-activated protein kinases (MAPKs) has been correlated with a more malignant phenotype in several tumor models in vivo. This study was designed to clarify the expression of MKP-1 in surgically resected hepatocellular carcinoma (HCC). Methods: We reviewed the cases of 77 patients who had undergone initial liver resection for HCC without preoperative treatment. Immunohistochemical analysis of MKP-1 was performed on paraffin-embedded tissues. The correlation between MKP-1 expression and clinical outcome was investigated. Results: Tumor cells were immunohistochemically stained for MKP-1 expression, and the same levels as in normal hepatocytes were detected in 66 (85%) of 77 HCC patients, being decreased in 11 (15%) HCCs. Decreased MKP-1 expression significantly correlated with serum α-fetoprotein levels and tumor size (p < 0.05). The disease-free survival rates in MKP-1-negative and -positive patients were 0 and 31.0% at 5 years, respectively (p < 0.01). The survival rates after a surgical resection in MKP-1-negative and -positive patients were 18.2 and 65.5% at 5 years, respectively (p < 0.01). Conclusions: The MKP-1 expression in HCC was an independent prognostic factor for outcome in HCC patients. In the future, it will be useful to explore whether the phosphatase expression might account for the response to HCC treatments targeting at MAPK activation. |
| تدمد: | 1423-0232 0030-2414 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6151fa0e0c10108c4eeae9585f32a9Test https://doi.org/10.1159/000089766Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....aa6151fa0e0c10108c4eeae9585f32a9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230232 00302414 |
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