Cholesterol induced heart valve inflammation and injury: efficacy of cholesterol lowering treatment
| العنوان: | Cholesterol induced heart valve inflammation and injury: efficacy of cholesterol lowering treatment |
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| المؤلفون: | Michael Kehdi, George S. Abela, Levi Fry, Heather De Feijter-Rupp, Layan Elkhatib, Abed Janoudi |
| المصدر: | Open Heart, Vol 7, Iss 2 (2020) Open Heart |
| بيانات النشر: | BMJ Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Aortic valve, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, pulmonary valve disease, medicine.medical_treatment, Hypercholesterolemia, Heart Valve Diseases, Ezetimibe, Simvastatin Drug Combination, Inflammation, 030204 cardiovascular system & hematology, Cholesterol, Dietary, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Ezetimibe, Valve replacement, Internal medicine, medicine, Animals, Humans, Heart valve, 030304 developmental biology, 0303 health sciences, Sclerosis, Endocarditis, Cholesterol, business.industry, Aortic and Vascular Disease, aortic valve disease, medicine.disease, Heart Valves, Disease Models, Animal, medicine.anatomical_structure, Endocrinology, chemistry, Simvastatin, lcsh:RC666-701, lipids (amino acids, peptides, and proteins), mitral regurgitation, Rabbits, atherosclerosis, Hydroxymethylglutaryl-CoA Reductase Inhibitors, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Infiltration (medical), medicine.drug |
| الوصف: | BackgroundHeart valves often undergo a degenerative process leading to mechanical dysfunction that requires valve replacement. This process has been compared with atherosclerosis because of shared pathology and risk factors. In this study, we aimed to elucidate the role of inflammation triggered by cholesterol infiltration and cholesterol crystals formation causing mechanical and biochemical injury in heart valves.MethodsHuman and atherosclerotic rabbit heart valves were evaluated. New Zealand White male rabbits were fed an enriched cholesterol diet alone or with simvastatin and ezetimibe simultaneous or after 6 months of initiating cholesterol diet. Inflammation was measured using C-reactive protein (CRP) and RAM 11 of tissue macrophage content. Cholesterol crystal presence and content in valves was evaluated using scanning electron microscopy.ResultsCholesterol diet alone induced cholesterol infiltration of valves with associated increased inflammation. Tissue cholesterol, CRP levels and RAM 11 were significantly lower in simvastatin and ezetimibe rabbit groups compared with cholesterol diet alone. However, the treatment was effective only when initiated with a cholesterol diet but not after lipid infiltration in valves. Aortic valve cholesterol content was significantly greater than all other cardiac valves. Extensive amounts of cholesterol crystals were noted in rabbit valves on cholesterol diet and in diseased human valves.ConclusionsPrevention of valve infiltration with cholesterol and reduced inflammation by simvastatin and ezetimibe was effective only when given during the initiation of high cholesterol diet but was not effective when given following infiltration of cholesterol into the valve matrix. |
| اللغة: | English |
| تدمد: | 2053-3624 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa28dcf98e25b74cb2733dbdc45b77efTest https://openheart.bmj.com/content/7/2/e001274.fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....aa28dcf98e25b74cb2733dbdc45b77ef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20533624 |
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