Surgery of Insular Diffuse Gliomas—Part 1: Transcortical Awake Resection Is Safe and Independently Improves Overall Survival
| العنوان: | Surgery of Insular Diffuse Gliomas—Part 1: Transcortical Awake Resection Is Safe and Independently Improves Overall Survival |
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| المؤلفون: | Fabrice Chrétien, Alexandre Roux, Catherine Oppenheim, Sophie Peeters, Pascale Varlet, Johan Pallud, Marc Zanello, Frédéric Dhermain, Bénédicte Trancart, Edouard Dezamis, Alessandro Moiraghi, Myriam Edjlali |
| المصدر: | Neurosurgery. 89:565-578 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Stereotactic biopsy, medicine.diagnostic_test, Brain Neoplasms, business.industry, Hazard ratio, Astrocytoma, Glioma, medicine.disease, Resection, Surgery, Diffuse Glioma, Treatment Outcome, Biopsy, Humans, Medicine, Neurology (clinical), Wakefulness, business, Retrospective Studies, Cohort study |
| الوصف: | BACKGROUND Insular diffuse glioma resection is at risk of vascular injury and of postoperative new neurocognitive deficits. OBJECTIVE To assess safety and efficacy of surgical management of insular diffuse gliomas. METHODS Observational, retrospective, single-institution cohort analysis (2005-2019) of 149 adult patients surgically treated for an insular diffuse glioma: transcortical awake resection with intraoperative functional mapping (awake resection subgroup, n = 61), transcortical asleep resection without functional mapping (asleep resection subgroup, n = 50), and stereotactic biopsy (biopsy subgroup, n = 38). All cases were histopathologically assessed according to the 2016 World Health Organization classification and cIMPACT-NOW update 3. RESULTS Following awake resection, 3/61 patients had permanent motor deficit, seizure control rates improved (89% vs 69% preoperatively, P = .034), and neurocognitive performance improved from 5% to 24% in tested domains, despite adjuvant oncological treatments. Resection rates were higher in the awake resection subgroup (median 94%) than in the asleep resection subgroup (median 46%; P |
| تدمد: | 1524-4040 0148-396X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1bffc4a654fbe6c8e8725068fcced4Test https://doi.org/10.1093/neuros/nyab254Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....aa1bffc4a654fbe6c8e8725068fcced4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244040 0148396X |
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