Myeloablative unrelated cord blood transplantation for acute leukemia patients between 50 and 55 years of age: single institutional retrospective comparison with patients younger than 50 years of age
| العنوان: | Myeloablative unrelated cord blood transplantation for acute leukemia patients between 50 and 55 years of age: single institutional retrospective comparison with patients younger than 50 years of age |
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| المؤلفون: | Nobuhiro Tsukada, Tohru Iseki, Aki Sato, Fumihiko Monma, Akira Tomonari, Takuhiro Yamaguchi, Arinobu Tojo, Jun Ooi, Tokiko Nagamura-Inoue, Shigetaka Asano, Kaoru Uchimaru, Seiko Kato, Senji Kasahara, Takaaki Konuma, Satoshi Takahashi |
| المصدر: | Annals of Hematology. 88:581-588 |
| بيانات النشر: | Springer Science and Business Media LLC, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Graft vs Host Disease, Cord Blood Stem Cell Transplantation, Hematopoietic stem cell transplantation, Recurrence, Internal medicine, medicine, Humans, Granulocyte Precursor Cells, Survival rate, Retrospective Studies, Acute leukemia, Leukemia, Hematology, business.industry, General Medicine, Middle Aged, Total body irradiation, Surgery, Survival Rate, Treatment Outcome, surgical procedures, operative, medicine.anatomical_structure, Cord blood, Acute Disease, Female, Bone marrow, business, Follow-Up Studies |
| الوصف: | Increasing recipient age is a well-known risk factor for graft-versus-host disease (GVHD) and treatment-related mortality (TRM) and has a negative impact on allogeneic hematopoietic stem cell transplantation. Since the incidence of severe GVHD after cord blood transplantation (CBT) is lower than that after transplants using bone marrow or mobilized peripheral blood grafts from adult cells, we should expect better outcomes from CBT in older patients. To evaluate the feasibility and efficacy of myeloablative unrelated CBT in patients aged between 50 and 55 years, we performed a retrospective comparison of 100 patients with acute leukemia who received cord blood grafts at our institution. Nineteen older patients (median age, 52; range, 50-55) and 81 younger patients (median, 36; range, 16-49) received a myeloablative conditioning regimen including 12 Gy of total body irradiation and chemotherapy. GVHD prophylaxis included cyclosporine with (n = 96) or without (n = 4) methotrexate. There were no significant differences in the incidences of grades II to IV acute GVHD, extensive-type chronic GVHD, TRM, and the probability of overall and disease-free survival between these groups. These results suggest that, in patients with acute leukemia, myeloablative CBT might be as safe and effective in patients aged between 50 and 55 years as in younger patients. |
| تدمد: | 1432-0584 0939-5555 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0d055a0d033007b782b44ee77c7732Test https://doi.org/10.1007/s00277-008-0641-2Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....aa0d055a0d033007b782b44ee77c7732 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320584 09395555 |
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