Omentin-1 in diabetes mellitus: A systematic review and meta-analysis
| العنوان: | Omentin-1 in diabetes mellitus: A systematic review and meta-analysis |
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| المؤلفون: | Xiongfeng Pan, Kwabena Acheampong, Aizhong Liu, Atipatsa C. Kaminga, Shi Wu Wen |
| المصدر: | PLoS ONE, Vol 14, Iss 12, p e0226292 (2019) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Type 2 diabetes, Biochemistry, Database and Informatics Methods, Endocrinology, Mathematical and Statistical Techniques, 0302 clinical medicine, Pregnancy, Lectins, Medicine and Health Sciences, Insulin, 030212 general & internal medicine, Enzyme-Linked Immunoassays, Database Searching, Multidisciplinary, Statistics, Metaanalysis, Research Assessment, Type 2 Diabetes, 3. Good health, Gestational diabetes, Meta-analysis, Physical Sciences, Cytokines, Medicine, Female, Research Article, Adult, medicine.medical_specialty, Systematic Reviews, Endocrine Disorders, Science, 030209 endocrinology & metabolism, Research and Analysis Methods, GPI-Linked Proteins, 03 medical and health sciences, Internal medicine, Diabetes mellitus, Diabetes Mellitus, medicine, Humans, Statistical Methods, Gestational Diabetes, Immunoassays, Diabetic Endocrinology, Type 1 diabetes, business.industry, Biology and Life Sciences, Type 2 Diabetes Mellitus, medicine.disease, Hormones, Confidence interval, Diabetes, Gestational, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Strictly standardized mean difference, Metabolic Disorders, Immunologic Techniques, business, Mathematics |
| الوصف: | Objective Previous studies found inconsistent results on the relationship between diabetes mellitus and concentrations of omentin-1. This study performed a systematic review and meta-analysis to summarize previous findings on this relationship. Methods Studies related to this outcome were obtained using a systematic search in the electronic databases of Cochrane Library, PubMed, Embase, SCOPUS, Google Scholar, gray literature and Web of Science in September 2019. The random effects model was used to measure the strength of the association between diabetes mellitus and concentrations of omentin-1, using standardized mean difference. Results Forty-two eligible studies were included in the final meta-analysis. There was no significant difference in omentin-1 concentration between patients with type 1 diabetes mellitus and the controls. On the other hand, lower concentration levels of omentin-1 were observed in patients with gestational diabetes mellitus (standardized mean difference:-0.44, 95% confidence interval:-0.76; -0.12, p = 0.007), or type 2 diabetes mellitus (standardized mean difference: -1.74, 95% confidence interval: -2.31; -1.16, p< 0.001) than in the controls. Conclusion Decreased omentin-1 concentrations may be an important indicator for gestational diabetes mellitus and type 2 diabetes mellitus. More studies are needed to validate this hypothesis and evaluate the role of omentin-1 concentrations in type 1 diabetes mellitus. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a872d0bf5a22d5a42d97b183ba8ba24dTest https://doaj.org/article/b61241456ef34adaba09da2e99ed9711Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a872d0bf5a22d5a42d97b183ba8ba24d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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