Lipoprotein-Associated Phospholipase A 2 Is an Independent Marker for Coronary Endothelial Dysfunction in Humans
| العنوان: | Lipoprotein-Associated Phospholipase A 2 Is an Independent Marker for Coronary Endothelial Dysfunction in Humans |
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| المؤلفون: | Lilach O. Lerman, Ryan J. Lennon, Eric H. Yang, Amir Lerman, Geralyn M. Pumper, Gregory W. Barsness, Charanjit S. Rihal, Joseph P. McConnell, Stacy J. Hartman |
| المصدر: | Arteriosclerosis, Thrombosis, and Vascular Biology. 26:106-111 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Endothelium, Coronary Artery Disease, Phospholipases A, Coronary artery disease, Coronary circulation, Predictive Value of Tests, Risk Factors, Coronary Circulation, Internal medicine, medicine, Humans, Endothelial dysfunction, Hypolipidemic Agents, Vascular disease, business.industry, Microcirculation, Lipoprotein-associated phospholipase A2, Middle Aged, medicine.disease, Coronary Vessels, Phospholipases A2, medicine.anatomical_structure, 1-Alkyl-2-acetylglycerophosphocholine Esterase, Cardiology, Female, Endothelium, Vascular, Cardiology and Cardiovascular Medicine, business, Biomarkers, Artery, Lipoprotein |
| الوصف: | Objective— The purpose of the current study was to determine whether lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) is associated with coronary endothelial dysfunction and is a predictor of endothelial dysfunction in humans. Methods and Results— Patients (172) with no significant coronary artery disease (2 were measured, and patients were divided into tertiles. Patients in tertiles 2 and 3 had a significantly lower change in coronary blood flow (63.8±73.2 and 32.0±71.7 versus 78.4±73.2%; P P 2 than those with normal endothelial function (246.2±71.6 versus 209±56.7 ng/mL; P =0.001). The odds ratio for coronary endothelial dysfunction in patients with Lp-PLA 2 in the highest tertile was 3.3 (95% CI, 1.6 to 6.6). Conclusions— Lp-PLA 2 is independently associated with coronary artery endothelial dysfunction and is a strong predictor of endothelial dysfunction in humans. |
| تدمد: | 1524-4636 1079-5642 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a866e223247d275f2ec16ee902aa9ea0Test https://doi.org/10.1161/01.atv.0000191655.87296.abTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a866e223247d275f2ec16ee902aa9ea0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244636 10795642 |
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