Introduction to immunotherapy for brain tumor patients: challenges and future perspectives
| العنوان: | Introduction to immunotherapy for brain tumor patients: challenges and future perspectives |
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| المؤلفون: | Noriyuki Kasahara, Hideho Okada, Megan Montoya |
| المصدر: | Neurooncol Pract Neuro-oncology practice, vol 7, iss 5 |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, medicine.medical_treatment, Brain tumor, Reviews, Medicine (miscellaneous), Vaccine Related, checkpoint, Rare Diseases, Clinical Research, glioma, vaccine, Internal medicine, Glioma, medicine, Cancer, 5.2 Cellular and gene therapies, business.industry, glioblastoma, Neurosciences, Immunotherapy, medicine.disease, Chimeric antigen receptor, Brain Disorders, Oncolytic virus, Brain Cancer, Radiation therapy, Orphan Drug, Immunization, Chimeric Antigen Receptor T-Cell Therapy, immunotherapy, business |
| الوصف: | Malignant gliomas, including glioblastoma (GBM) as the most aggressive type of adult CNS tumors, are notoriously resistant to current standard of care treatments, including surgery, systemic chemotherapy, and radiation therapy (RT). This lack of effective treatment options highlights the urgent need for novel therapies, including immunotherapies. The overarching goal of immunotherapy is to stimulate and activate the patient’s immune system in a targeted manner to kill tumor cells. The success of immunotherapeutic interventions in other cancer types has led to interest in and evaluation of various experimental immunotherapies in patients with malignant gliomas. However, these primary malignant brain tumors present a challenge because they exist in a vital and sensitive organ with a unique immune environment. The challenges and current status of experimental immunotherapeutic approaches, including vaccines, immune-checkpoint blockade, chimeric antigen receptor T-cell therapy, and oncolytic viruses will be discussed, as well as the potential for combinatorial therapies. |
| وصف الملف: | application/pdf |
| تدمد: | 2054-2585 2054-2577 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a861deeae146fa68402db7ad1ea1cfaaTest https://doi.org/10.1093/nop/npaa007Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a861deeae146fa68402db7ad1ea1cfaa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20542585 20542577 |
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