The Molecular Pathology of Myelodysplastic Syndrome
| العنوان: | The Molecular Pathology of Myelodysplastic Syndrome |
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| المؤلفون: | Torsten Haferlach |
| المصدر: | Pathobiology. 86:24-29 |
| بيانات النشر: | S. Karger AG, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, IDH1, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Risk groups, Internal medicine, medicine, Humans, Pathology, Molecular, Molecular Biology, Cytopenia, business.industry, Molecular pathology, Myelodysplastic syndromes, Cytogenetics, Cell Biology, General Medicine, Phosphoproteins, Prognosis, medicine.disease, Isocitrate Dehydrogenase, International Prognostic Scoring System, Myelodysplastic Syndromes, 030220 oncology & carcinogenesis, Mutation, RNA Splicing Factors, business, Who classification, Biomarkers, 030215 immunology |
| الوصف: | The diagnosis and classification of myelodysplastic syndromes (MDS) are based on cytomorphology and cytogenetics (WHO classification). Prognosis is best defined by the Revised International Prognostic Scoring System (IPSS-R). In recent years, an increasing number of molecular aberrations have been discovered. They are already included in the classification (e.g., SF3B1) and, more importantly, have emerged as valuable markers for better classification, particularly for defining risk groups. Mutations in genes such as SF3B1 and IDH1/2 have already had an impact on targeted treatment approaches in MDS. |
| تدمد: | 1423-0291 1015-2008 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8521acfffdfaa638a8bcb6e45288aebTest https://doi.org/10.1159/000488712Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a8521acfffdfaa638a8bcb6e45288aeb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230291 10152008 |
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