Nuclear Localization of Immunoreactive β‐Catenin Is Specific to Familial Adenomatous Polyposis in Papillary Thyroid Carcinoma
| العنوان: | Nuclear Localization of Immunoreactive β‐Catenin Is Specific to Familial Adenomatous Polyposis in Papillary Thyroid Carcinoma |
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| المؤلفون: | Ja-Mun Chong, Masashi Fukayama, Shinichiro Shimizu, Nobuaki Funata, Michiko Miyaki, Hiroshi Kashiwagi, Tunekazu Hishima, Katsumi Kurihara, Hideaki Nagai |
| المصدر: | Japanese Journal of Cancer Research : Gann |
| بيانات النشر: | Blackwell Publishing Ltd, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Adult, Cancer Research, Pathology, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, endocrine system diseases, Adolescent, Adenomatous polyposis coli, Papillary carcinoma, Familial adenomatous polyposis, Thyroid carcinoma, medicine, Humans, Thyroid Neoplasms, neoplasms, Cellular localization, beta Catenin, Aged, Aged, 80 and over, Cell Nucleus, biology, β‐Catenin, business.industry, Thyroid, Middle Aged, medicine.disease, Immunohistochemistry, digestive system diseases, Carcinoma, Papillary, Cell nucleus, Cytoskeletal Proteins, medicine.anatomical_structure, Oncology, Adenomatous Polyposis Coli, Catenin, biology.protein, Trans-Activators, Female, business, Rapid Communication |
| الوصف: | Thyroid carcinoma is the first symptom in some patients with familial adenomatous polyposis (FAP). We evaluated the cellular localization of beta-catenin in thyroid carcinomas associated (n = 4) or not associated (n = 173) with FAP, since loss of functional protein of the adenomatous polyposis coli (APC) gene leads to nuclear accumulation of beta-catenin in adenomas and carcinomas of the FAP colon. Immunoreactive beta-catenin was demonstrated at the cell membrane of glandular cells of the non-neoplastic thyroid and non-FAP carcinomas. On the other hand, cytoplasmic and nuclear accumulation of beta-catenin is specific to FAP-associated papillary carcinomas. The abnormality in the APC / beta-catenin pathway is thus also important in FAP-associated thyroid carcinoma, and beta-catenin immunohistochemistry is a feasible screening method to identify occult FAP in young patients with thyroid tumors. |
| اللغة: | English |
| تدمد: | 1876-4673 0910-5050 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82cc042f0534b62d9701cf6d7d7b031Test http://europepmc.org/articles/PMC5926294Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a82cc042f0534b62d9701cf6d7d7b031 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18764673 09105050 |
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