Patients with diffuse large B-cell lymphoma of germinal center origin with BCL2 translocations have poor outcome, irrespective of MYC status:A report from an international DLBCL rituximab-CHOP consortium program study
| العنوان: | Patients with diffuse large B-cell lymphoma of germinal center origin with BCL2 translocations have poor outcome, irrespective of MYC status:A report from an international DLBCL rituximab-CHOP consortium program study |
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| المؤلفون: | Jane N. Winter, Huan You Wang, Stacey S O'Neill, Santiago Montes-Moreno, J. Han van Krieken, Govind Bhagat, Wei-Min Liu, April Chiu, Yong Li, Stephan Dirnhofer, Cherie H. Dunphy, Karen Dybkær, Brad S. Kahl, Zijun Y. Xu-Monette, Emanuele S.G. d'Amore, Yan Li, Ken H. Young, Eric D. His, Miguel A. Piris, Carlo Visco, L. Jeffrey Medeiros, Xiaoying Zhao, Qin Huang, Ronald S. Go, Maurilio Ponzoni, Attilio Orazi, Michael Boe Møller, Roberto N. Miranda, Alexander Tzankov, Weiyun Z. Ai, Andrés J.M. Ferreri, Lin Wu, Yu Chuan Tai, Youli Zu, William W.L. Choi, X. Frank Zhao |
| المساهمون: | Visco, C, Tzankov, A, Xu Monette, Zy, Miranda, Rn, Tai, Yc, Li, Y, Liu, Wm, D'Amore, E, Montes Moreno, S, Dybkaer, K, Chiu, A, Orazi, A, Zu, Y, Bhagat, G, Wang, Hy, Dunphy, Ch, O' Neill, S, Hsi, Ed, Zhao, Xf, Choi, Ww, Zhao, X, van Krieken, Jh, Huang, Q, Ai, W, Ponzoni, Maurilio, Ferreri, Aj, Kahl, B, Winter, Jn, Go, R, Dirnhofer, S, Piris, Ma, Møller, Mb, Wu, L, Medeiros, Lj, Young, K. H. |
| المصدر: | Visco, C, Tzankov, A, Xu-Monette, Z Y, Miranda, R N, Tai, Y C, Li, Y, Liu, W M, d'Amore, E S G, Li, Y, Montes-Moreno, S, Dybkær, K, Chiu, A, Orazi, A, Zu, Y, Bhagat, G, Wang, H Y, Dunphy, C H, His, E D, Zhao, X F, Choi, W W L, Zhao, X, Han van Krieken, J, Huang, Q, Ai, W, O'Neill, S, Ponzoni, M, Ferreri, A J M, Kahl, B S, Winter, J N, Go, R S, Dirnhofer, S, Piris, M A, Møller, M B, Wu, L, Medeiros, L J & Young, K H 2013, ' Patients with diffuse large B-cell lymphoma of germinal center origin with BCL2 translocations have poor outcome, irrespective of MYC status : A report from an international DLBCL rituximab-CHOP consortium program study ', Haematologica, vol. 98, no. 2, pp. 255-263 . https://doi.org/10.3324/haematol.2012.066209Test Visco, C, Tzankov, A, Xu-Monette, Z Y, Miranda, R N, Tai, Y C, Li, Y, Liu, W-M, d'Amore, E S G, Li, Y, Montes-Moreno, S, Dybkaer, K, Chiu, A, Orazi, A, Zu, Y, Bhagat, G, Wang, H-Y, Dunphy, C H, O' Neill, S, Hsi, E D, Zhao, X F, Choi, W W L, Zhao, X, van Krieken, J H, Huang, Q, Ai, W, Ponzoni, M A, Ferreri, A J M, Kahl, B S, Winter, J N, Go, R S, Dirnhofer, S, Piris, M A, Møller, M B, Wu, L, Medeiros, L J & Young, K H 2012, ' Patients with diffuse large B cell lymphoma of germinal center origin with BCL2 translocations have poor outcome, irrespective of MYC status : a report from an International DLBCL rituximab-CHOP Consortium Program Study ', Haematologica . https://doi.org/10.3324/haematol.2012.066209Test Haematologica, 98, 255-63 Haematologica, 98, 2, pp. 255-63 |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Lymphoma, Genes, myc, CHOP, Translocation, Genetic, Antibodies, Monoclonal, Murine-Derived, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, Monoclonal, Antineoplastic Combined Chemotherapy Protocols, 80 and over, Aged, 80 and over, 0303 health sciences, medicine.diagnostic_test, Articles, Hematology, myc, Middle Aged, Prognosis, Translational research Tissue engineering and pathology [ONCOL 3], Diffuse, 3. Good health, Adolescent, Adult, Aged, Chromosomes, Human, Pair 14, Chromosomes, Human, Pair 18, Cyclophosphamide, Doxorubicin, Female, Gene Expression Profiling, Germinal Center, Humans, Lymphoma, Large B-Cell, Diffuse, Prednisone, Proto-Oncogene Proteins c-bcl-2, Vincristine, Young Adult, 030220 oncology & carcinogenesis, Rituximab, medicine.drug, Human, Murine-Derived, Translocation, Biology, Antibodies, Chromosomes, 03 medical and health sciences, Genetic, medicine, Large B-Cell, 030304 developmental biology, Pair 18, Pair 14, Germinal center, medicine.disease, Gene expression profiling, Genes, Cancer research, Diffuse large B-cell lymphoma, Fluorescence in situ hybridization |
| الوصف: | Contains fulltext : 118936.pdf (Publisher’s version ) (Open Access) Diffuse large B-cell lymphoma can be classified by gene expression profiling into germinal center and activated B-cell subtypes with different prognoses after rituximab-CHOP. The importance of previously recognized prognostic markers, such as Bcl-2 protein expression and BCL2 gene abnormalities, has been questioned in the new therapeutic era. We analyzed Bcl-2 protein expression, and BCL2 and MYC gene abnormalities by interphase fluorescence in situ hybridization in 327 patients with de novo disease treated with rituximab-CHOP. Isolated BCL2 and MYC rearrangements were not predictive of outcome in our patients as a whole, but only in those with the germinal center subtype of lymphoma. The prognostic relevance of isolated MYC rearrangements was weaker than that of BCL2 isolated translocations, but was probably limited by the rarity of the rearrangements. Seven of eight patients with double hit lymphoma had the germinal center subtype with poor outcome. The germinal center subtype patients with isolated BCL2 translocations had significantly worse outcome than the patients without BCL2 rearrangements (P=0.0002), and their outcome was similar to that of patients with the activated B-cell subtype (P=0.30), but not as bad as the outcome of patients with double hit lymphoma (P |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0390-6078 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a81ca88fbd1cf8a329c97836fa9b73Test https://vbn.aau.dk/da/publications/fef335cd-6174-420d-8875-8dc7897ec7d3Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a7a81ca88fbd1cf8a329c97836fa9b73 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03906078 |
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