Inhibition of Insulin, Glucose-Dependant Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide-1 (GLP-1) Secretion by Octreotide has no Effect on Post-Heparin Plasma Lipoprotein Lipase Activity
| العنوان: | Inhibition of Insulin, Glucose-Dependant Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide-1 (GLP-1) Secretion by Octreotide has no Effect on Post-Heparin Plasma Lipoprotein Lipase Activity |
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| المؤلفون: | L R Ranganath, J M Beety, Linda M. Morgan |
| المصدر: | Hormone and Metabolic Research. 31:262-266 |
| بيانات النشر: | Georg Thieme Verlag KG, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Adult, Blood Glucose, endocrine system, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, Octreotide, Gastric Inhibitory Polypeptide, Biochemistry, Glucagon, Endocrinology, Gastric inhibitory polypeptide, Glucagon-Like Peptide 1, Internal medicine, Dietary Carbohydrates, Humans, Insulin, Medicine, Protein Precursors, Lipoprotein lipase, Heparin, business.industry, digestive, oral, and skin physiology, Biochemistry (medical), Fasting, General Medicine, Glucagon-like peptide-1, Hormones, Peptide Fragments, Kinetics, Lipoprotein Lipase, Postprandial, Female, business, hormones, hormone substitutes, and hormone antagonists, Hormone, medicine.drug |
| الوصف: | This study examines the immediate effect of modulating postprandial insulin and insulinotropic hormone (glucose-dependent insulinotropic polypeptide, GIP; glucagon-like peptide-1, GLP-1) secretion on the activation of lipoprotein lipase (LPL) in six lean and six obese age-matched women. Subjects were given, on two separate occasions, 340 kcal of carbohydrate alone or combined with an IV infusion of octreotide, (100 microg infusion from 30 min before the meal for 150 min). Post-heparin LPL activity (10,000 U) was measured on each occasion 120 minutes post-carbohydrate. Following oral carbohydrate postprandial plasma insulin levels were significantly higher in obese subjects than in lean (p < 0.01). Glucose tolerance was slightly impaired in obese subjects. Insulin, GIP and GLP-1 secretion post-carbohydrate was markedly reduced by octreotide in lean and obese subjects. LPL activity was similar in the two groups after carbohydrate administration and was unaffected by octreotide. Inhibition of postprandial insulin, GIP and GLP-1 secretion acutely did not reduce post-heparin LPL activity either in lean or obese subjects. |
| تدمد: | 1439-4286 0018-5043 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a729f8e37e9173181afe16896eff7398Test https://doi.org/10.1055/s-2007-978729Test |
| رقم الانضمام: | edsair.doi.dedup.....a729f8e37e9173181afe16896eff7398 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14394286 00185043 |
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