Population pharmacokinetics and exposure‐response analysis of tigecycline in patients with hospital‐acquired pneumonia
| العنوان: | Population pharmacokinetics and exposure‐response analysis of tigecycline in patients with hospital‐acquired pneumonia |
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| المؤلفون: | Han Yan, Hoan Linh Banh, Huan-De Li, Ping Xu, Feng Wang, Yangang Zhou, Bikui Zhang, Wu Liang, Da-Xiong Xiang |
| المصدر: | British Journal of Clinical Pharmacology. 87:2838-2846 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Population, Minocycline, Microbial Sensitivity Tests, Tigecycline, medicine.disease_cause, Hospital-acquired pneumonia, Logistic regression, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, Internal medicine, medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, education, Pharmacology, Volume of distribution, Creatinine, education.field_of_study, Pseudomonas aeruginosa, business.industry, Pneumonia, medicine.disease, Hospitals, Anti-Bacterial Agents, chemistry, business, medicine.drug |
| الوصف: | BACKGROUND Tigecycline has been widely used to treat hospital-acquired pneumonia (HAP) off-label since it is effective against a wide range of multidrug-resistant bacteria. However, no recommended dosage for this indication has been evaluated, resulting in possible inadequate treatment. AIMS The aims of this study are to establish the population pharmacokinetic (PPK) model of tigecycline in Chinese patients with HAP, as well as to evaluate the exposure-response relationship for the treatment of HAP with multidrug-resistant gram-negative bacteria. METHODS A PPK analysis of tigecycline was conducted on pooled data from 328 blood samples obtained from 89 patients with HAP. Tigecycline plasma concentrations were measured by a two-dimensional liquid chromatographic system and the data were analysed using Phoenix NLMETM software. Exposure-response analyses for efficacy were performed based on the data from 79 HAP patients with multidrug-resistant gram-negative infections. Classification and regression tree and logistic regression analyses were employed to identify which pharmacokinetic-pharmacodynamic (PK-PD) indices and magnitudes were the significant predictors of tigecycline efficacy. RESULTS A two-compartment model with zero-order absorption and first-order elimination adequately described the data. A larger body weight was associated with increased central volume of distribution and clearance (P |
| تدمد: | 1365-2125 0306-5251 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fd2c08de0698106d4bce21525f8e5dTest https://doi.org/10.1111/bcp.14692Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a6fd2c08de0698106d4bce21525f8e5d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652125 03065251 |
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