Risk factors for positive sentinel lymph nodes in head and neck melanoma — a survival analysis

التفاصيل البيبلوغرافية
العنوان: Risk factors for positive sentinel lymph nodes in head and neck melanoma — a survival analysis
المؤلفون: André Bandiera de Oliveira Santos, Neide Lira Bonachela, Luiz Paulo Kowalski
المصدر: Brazilian Journal of Otorhinolaryngology, Vol 87, Iss 1, Pp 103-109 (2021)
Brazilian Journal of Otorhinolaryngology, Volume: 87, Issue: 1, Pages: 103-109, Published: 15 MAR 2021
Brazilian Journal of Otorhinolaryngology v.87 n.1 2021
Brazilian Journal of Otorhinolaryngology
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial (ABORL-CCF)
instacron:ABORL-CCF
بيانات النشر: Elsevier, 2021.
سنة النشر: 2021
مصطلحات موضوعية: medicine.medical_specialty, Skin Neoplasms, Mitotic index, Survival, Prognóstico, Sentinel lymph node, 030207 dermatology & venereal diseases, 03 medical and health sciences, Head and neck, 0302 clinical medicine, Risk Factors, Biopsy, Sobrevida, medicine, Humans, Melanoma, Survival analysis, Retrospective Studies, medicine.diagnostic_test, business.industry, Cabeça e pescoço, Linfonodo sentinela, medicine.disease, Prognosis, lcsh:Otorhinolaryngology, Survival Analysis, lcsh:RF1-547, Otorhinolaryngology, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Cutaneous melanoma, Lymph Nodes, Radiology, Lymph, business
الوصف: Introduction: Sentinel lymph node biopsy is the gold standard procedure for head and neck cutaneous melanoma staging. Objective: To evaluate the technical aspects, positivity and prognostic effect of the cervico-facial sentinel lymph node biopsy. Methods: Retrospective, unicentric study. From 2009 to 2014, 49 patients with cutaneous melanoma of the head and neck underwent surgery at Instituto do Câncer do Estado de São Paulo (ICESP). Results: Of the 49 patients, 5 had cervical metastasis at the moment of admission. Clark, Breslow and mitotic index were predictors of death. Among the 31 patients undergoing sentinel lymph node biopsy, 3 had positive sentinel lymph nodes (9.7%). Deaths were recorded in two of the cases with positive sentinel lymph nodes (66.6%), and in 5 (17.8%) of the patients with negative lymph nodes. The mean Breslow index was 11.3 mm for primary melanomas with positive sentinel lymph nodes and 4.3 mm for those with negative sentinel lymph nodes. Positivity was associated with Clark and Breslow levels. Malar location showed a protective effect on prognosis. The mean survival for patients with a mitotic index 3.5. Conclusion: The frequency of positive sentinel lymph node biopsy in patients with malignant melanoma of the head and neck was lower than in other studies, although the sample consisted of individuals with advanced melanomas. The mitotic index was important for prognosis prediction. Resumo Introdução: A biópsia de linfonodo sentinela é o padrão-ouro para estadiamento de melanomas cutâneos em cabeça e pescoço. Objetivo: Avaliar aspectos técnicos, positividade e efeito prognóstico da pesquisa de linfonodo sentinela cervico-facial. Método: Estudo retrospectivo, unicêntrico. Entre 2009 e 2014, 49 pacientes com melanoma cutâneo de cabeça e pescoço foram operados no Instituto do Câncer do Estado de São Paulo (ICESP). Resultado: Dos 49 pacientes, cinco tiveram metástases cervicais detectáveis à admissão. Níveis de Clark e Breslow e índice mitótico foram preditores de risco de óbito. Entre os 31 pacientes submetidos à biópsia de linfonodo sentinela, três tiveram resultados positivos (9,7%). Faleceram dois (66,6%) dos portadores de micrometástases e cinco (17,8%) entre os pacientes com linfonodos sentinela negativos. A média do índice de Breslow foi de 11,3 mm entre os casos positivos e 4,3 mm nos negativos. A positividade foi associada aos níveis de Clark e Breslow. A localização malar teve efeito protetor. A média de tempo de sobrevivência dos pacientes com índice mitótico abaixo de 3,5 foi de 181 meses e para aqueles com índice mitótico acima de 3,5 foi de 63,4 meses. Conclusão: A frequência de linfonodo sentinela positivo foi mais baixa do que a encontrada em outros estudos, apesar de a amostra ter sido composta por melanomas avançados. O índice mitótico foi importante na predição de prognóstico.
وصف الملف: text/html
اللغة: English
تدمد: 1808-8694
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c18f013d3dba48ba63f2daa36e2488Test
http://www.sciencedirect.com/science/article/pii/S1808869420301932Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....a6c18f013d3dba48ba63f2daa36e2488
قاعدة البيانات: OpenAIRE