Adverse muscle composition is linked to poor functional performance and metabolic comorbidities in NAFLD
| العنوان: | Adverse muscle composition is linked to poor functional performance and metabolic comorbidities in NAFLD |
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| المؤلفون: | Mattias Ekstedt, Jennifer Linge, Olof Dahlqvist Leinhard |
| المصدر: | JHEP Reports, Vol 3, Iss 1, Pp 100197-(2021) JHEP Reports |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Sarcopenia, Myosteatosis, Skeletal muscle, AMC, Type 2 diabetes, CHD, coronary heart disease, Grip strength, Liver disease, Diabetes mellitus, FFMV, fat-tissue free muscle volume, non-alcoholic steatohepatitis, Non-alcoholic steatohepatitis, PDFF, PDFF, proton density fat fraction, Immunology and Allergy, Fatty liver, coronary heart disease, Cardiovascular disease, DXA, Gastroenterology, muscle fat infiltration, Magnetic resonance imaging, NAFLD, proton density fat fraction, T2D, medicine.anatomical_structure, fat-tissue free muscle volume, FIB-4, fibrosis-4, HbA1c, Research Article, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, NASH, non-alcoholic steatohepatitis, dual-energy x-ray absorptiometry, FFMV, T2D, type 2 diabetes, Gastroenterology and Hepatology, MFI, muscle fat infiltration, DXA, dual-energy x-ray absorptiometry, glycated haemoglobin, MFI, virtual control group, Internal medicine, Gastroenterologi, Internal Medicine, medicine, VCG, virtual control group, FIB-4, fibrosis-4, lcsh:RC799-869, adverse muscle composition, CHD, Hepatology, business.industry, medicine.disease, Comorbidity, non-alcoholic fatty liver disease, NASH, AMC, adverse muscle composition, HbA1c, glycated haemoglobin, lcsh:Diseases of the digestive system. Gastroenterology, type 2 diabetes, VCG, business |
| الوصف: | Background & Aims Sarcopenia and frailty are recognised as important factors in later stages of liver disease. However, their role in non-alcoholic fatty liver disease (NAFLD) is not yet fully understood. In this study we investigate the associations of MRI-measured adverse muscle composition (AMC: low muscle volume and high muscle fat) with poor function, sarcopenia, and metabolic comorbidity within NAFLD in the large UK Biobank imaging study. Methods A total of 9,545 participants were included. Liver fat, fat-tissue free muscle volume, and muscle fat infiltration were quantified using a rapid MRI protocol and automated image analysis (AMRA® Researcher). For each participant, a personalised muscle volume z-score (sex- and body size-specific) was calculated and combined with muscle fat infiltration for AMC detection. The following outcomes were investigated: functional performance (hand grip strength, walking pace, stair climbing, falls) and metabolic comorbidities (coronary heart disease, type 2 diabetes). Sarcopenia was detected by combining MRI thresholds for low muscle quantity and low hand grip strength according to the European working group definition. Results The prevalence of sarcopenia in NAFLD (1.6%) was significantly lower (p Graphical abstract Highlights • The role of sarcopenia and frailty in NAFLD is not yet fully understood. • Magnetic resonance imaging enables quantification of muscle composition. • Myosteatosis in combination with low muscle volume characterises an adverse muscle composition. • Adverse muscle composition is a novel NAFLD phenotype associated with poor function and metabolic comorbidity. • Sarcopenia guidelines can be strengthened by including cut-offs for muscle fat. |
| وصف الملف: | application/pdf |
| تدمد: | 2589-5559 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64b7d5e87e73ceb0598021536bc3699Test https://doi.org/10.1016/j.jhepr.2020.100197Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a64b7d5e87e73ceb0598021536bc3699 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25895559 |
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