Medical care from childhood to adulthood in Type 1 and Type 2 diabetes
| العنوان: | Medical care from childhood to adulthood in Type 1 and Type 2 diabetes |
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| المؤلفون: | N. K. Maclaren, S. Ten, Giulia Costi |
| المصدر: | Journal of Endocrinological Investigation. 24:692-707 |
| بيانات النشر: | Springer Science and Business Media LLC, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Pediatrics, Adolescent, Hearing loss, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, Disease, DNA, Mitochondrial, Endocrinology, Diabetes mellitus, Internal medicine, medicine, Humans, Family history, Risk factor, Child, Autoantibodies, business.industry, Infant, Newborn, Infant, medicine.disease, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Child, Preschool, Etiology, medicine.symptom, Differential diagnosis, business |
| الوصف: | Diabetes mellitus comprises a heterogeneous group of diseases that have in common the development of macro- and microvascular complications. It is now possible to identify subjects at high risk of Type 1 or Type 2 diabetes, especially in the patient's family members. Preventive interventions are quickly becoming available, and can help delay the onset of the disease and thereby reduce complications in these subjects. Furthermore the correct etiological diagnosis of diabetes is fundamental in providing the best treatment for the patient. Maturity-onset diabetes of the young (MODY) syndrome should be suspected in cases of a subtle onset of diabetes and autosomal dominant inheritance. Mitochondrial DNA mutations should be considered when a diabetic patient also suffers from deafness or if there is a family history of this combination in the mother side of the family. Atypical diabetes has to be identified by the physician to avoid mistakes when the patient enters the non-insulin-dependent phase. In the case of Wolfram's syndrome a gene analysis for each family member should be performed to identify heterozygote subjects. Recently, many discoveries in genetics help us better understand the pathogenesis of the diseases and diagnose the monogenic form of diabetes more easily. If all family members are followed in the same center, clues from the family history are readily available for differential diagnosis and preventive interventions can be established more effectively. |
| تدمد: | 1720-8386 0391-4097 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d9007538ecd9be3e83308f88221f6cTest https://doi.org/10.1007/bf03343914Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a5d9007538ecd9be3e83308f88221f6c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17208386 03914097 |
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