Cyclophosphamide type I hypersensitivity in systemic lupus erythematosus
| العنوان: | Cyclophosphamide type I hypersensitivity in systemic lupus erythematosus |
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| المؤلفون: | C Y Tang, Khai Pang Leong, Julian Thumboo, Bernard Yu-Hor Thong, E T Koh |
| المصدر: | Lupus. 11:127-129 |
| بيانات النشر: | SAGE Publications, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Hypersensitivity, Immediate, China, medicine.medical_specialty, Adolescent, Cyclophosphamide, 030204 cardiovascular system & hematology, Drug Hypersensitivity, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, immune system diseases, Internal medicine, medicine, Humans, Lupus Erythematosus, Systemic, skin and connective tissue diseases, 030203 arthritis & rheumatology, Lupus erythematosus, Angioedema, business.industry, medicine.disease, Hypersensitivity reaction, Immunology, Urticaria pigmentosa, Female, medicine.symptom, business, Anaphylaxis, medicine.drug, Type I hypersensitivity |
| الوصف: | Cyclophosphamide is an important immunosuppressive agent in the treatment of many rheumatic diseases. Urticaria and anaphylaxis to intravenous cyclophosphamide (i.v. CYC) have been reported in patients with haematological and solid organ malignancies. This is the first report in the rheumatology literature of a type I hypersensitivity reaction following monthly i.v. CYC. An 18-year-old girl with systemic lupus erythematosus (SLE) developed generalized urticaria (without concomitant angioedema or anaphylaxis) following i.v. CYC. She had previously developed life threatening angioedema following a respiratory tract infection. She successfully completed regular pulse i.v. CYC with pre-medication with anti-histamine. In the absence of a severe type I hypersensitivity reaction and other suitable immunosuppressive agents, i.v. CYC may be safely continued with pre-medication and careful monitoring during each infusion. |
| تدمد: | 1477-0962 0961-2033 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56aed939f3bda3464c9962b74080d6aTest https://doi.org/10.1191/0961203302lu140crTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a56aed939f3bda3464c9962b74080d6a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14770962 09612033 |
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