Cerebral Blood Flow and Glucose Metabolism Measured With Positron Emission Tomography Are Decreased in Human Type 1 Diabetes
| العنوان: | Cerebral Blood Flow and Glucose Metabolism Measured With Positron Emission Tomography Are Decreased in Human Type 1 Diabetes |
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| المؤلفون: | Marc C. Huisman, Nikie J. Hoetjes, Adriaan A. Lammertsma, Michaela Diamant, Lothar A. Schwarte, Richard G. IJzerman, Larissa W. van Golen |
| المساهمون: | Internal medicine, Radiology and nuclear medicine, Anesthesiology, NCA - Neurobiology of mental health, ICaR - Circulation and metabolism, Neuroscience Campus Amsterdam - Neurobiology of Mental Health |
| المصدر: | Diabetes, 62(8), 2898-2904. American Diabetes Association Inc. van Golen, L W, Huisman, M C, IJzerman, R G, Hoetjes, N J, Schwarte, L A, Lammertsma, A A & Diamant, M 2013, ' Cerebral Blood Flow and Glucose Metabolism Measured With Positron Emission Tomography Are Decreased in Human Type 1 Diabetes ', Diabetes, vol. 62, no. 8, pp. 2898-2904 . https://doi.org/10.2337/db12-1159Test van Golen, L W, Huisman, M C, IJzerman, R G, Hoetjes, N J, Schwarte, L A, Lammertsma, A A & Diamant, M 2013, ' Cerebral Blood Flow and Glucose Metabolism Measured With Positron Emission Tomography Are Decreased in Human Type 1 Diabetes ', Diabetes, vol. 62, no. 8, pp. 2898-2904 . https://doi.org/10.2337/db12-1159/-DC1Test Diabetes |
| بيانات النشر: | American Diabetes Association, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Carbohydrate metabolism, Pathophysiology, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Brain positron emission tomography, Hyperinsulinemia, Humans, Radionuclide Imaging, Original Research, Type 1 diabetes, Human Growth Hormone, business.industry, Insulin, Microangiopathy, Brain, Middle Aged, medicine.disease, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Glucose, Endocrinology, Cerebral blood flow, Cerebrovascular Circulation, business |
| الوصف: | Subclinical systemic microvascular dysfunction exists in asymptomatic patients with type 1 diabetes. We hypothesized that microangiopathy, resulting from long-standing systemic hyperglycemia and hyperinsulinemia, may be generalized to the brain, resulting in changes in cerebral blood flow (CBF) and metabolism in these patients. We performed dynamic [15O]H2O and [18F]-fluoro-2-deoxy-d-glucose brain positron emission tomography scans to measure CBF and cerebral glucose metabolism (CMRglu), respectively, in 30 type 1 diabetic patients and 12 age-matched healthy controls after an overnight fast. Regions of interest were automatically delineated on coregistered magnetic resonance images and full kinetic analysis was performed. Plasma glucose and insulin levels were higher in patients versus controls. Total gray matter CBF was 9%, whereas CMRglu was 21% lower in type 1 diabetic subjects versus control subjects. We conclude that at real-life fasting glucose and insulin levels, type 1 diabetes is associated with decreased resting cerebral glucose metabolism, which is only partially explained by the decreased CBF. These findings suggest that mechanisms other than generalized microangiopathy account for the altered CMRglu observed in well-controlled type 1 diabetes. |
| تدمد: | 1939-327X 0012-1797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e28766ecec959f7a55fb00d978ffefTest https://doi.org/10.2337/db12-1159Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a4e28766ecec959f7a55fb00d978ffef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
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