Impaired Contraction and Endothelium-Dependent Relaxation in Isolated Resistance Vessels from Patients with Insulin-Dependent Diabetes Mellitus
| العنوان: | Impaired Contraction and Endothelium-Dependent Relaxation in Isolated Resistance Vessels from Patients with Insulin-Dependent Diabetes Mellitus |
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| المؤلفون: | Paul G. McNally, Andrew C. Burden, John R. Hearnshaw, Herbert Thurston, Timothy J. Rimmer, Pamela A.C. Watt |
| المصدر: | Clinical Science. 87:31-36 |
| بيانات النشر: | Portland Press Ltd., 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Adult, Male, Nitroprusside, medicine.medical_specialty, Endothelium, Bradykinin, Vasodilation, In Vitro Techniques, Muscle, Smooth, Vascular, Norepinephrine, chemistry.chemical_compound, Internal medicine, Humans, Medicine, business.industry, Angiotensin II, Microangiopathy, Arteries, General Medicine, medicine.disease, Acetylcholine, Diabetes Mellitus, Type 1, medicine.anatomical_structure, Endocrinology, chemistry, Vasoconstriction, Potassium, Vascular resistance, Female, Vascular Resistance, Endothelium, Vascular, Sodium nitroprusside, medicine.symptom, business, Diabetic Angiopathies, Muscle Contraction, medicine.drug |
| الوصف: | 1. An increase in capillary blood flow and pressure has been implicated in the pathogenesis of diabetic microangiopathy. Abnormal vascular reactivity of the resistance vasculature may play a contributory role by permitting alterations in regional haemodynamics. 2. We have studied the contractile behavior of isolated resistance arteries from normotensive patients with insulin-dependent diabetes mellitus and non-diabetic matched control subjects. Contractile responses to potassium (123 mmol/l), noradrenaline (10−8 to 3 × 10−5 mol/l) and angiotensin II (10−11 to 3 × 10−8 mol/l) were recorded. Relaxation studies were performed in maximally contracted vessels using acetylcholine (10−8 to 10−5 mol/l) and bradykinin (10−9 to 10−6 mol/l) (endothelium-dependent) and sodium nitroprusside (10−9 to 10−5 mol/l) (endothelium-independent). 3. The maximal contractile responses to potassium (P < 0.05), noradrenaline (P < 0.01) and angiotensin II (P < 0.01) were depressed in diabetic patients. Relaxation to acetylcholine was impaired (P < 0.05), but was normal with bradykinin and sodium nitroprusside. 4. These results suggest that there may be a defect in the endothelial cell acetylcholine receptor excitation-coupling in diabetes mellitus rather than a decreased ability to synthesize and release endothelium-derived relaxing factor. Impaired contraction and endothelium-dependent relaxation of resistance arteries in diabetic patients may contribute to the development of diabetic microangiopathy by causing an increase in tissue blood flow, a rise in capillary pressure and, as a result, an increase in vascular permeability. |
| تدمد: | 1470-8736 0143-5221 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4cf6470570720a61f05ee7b75bab207Test https://doi.org/10.1042/cs0870031Test |
| رقم الانضمام: | edsair.doi.dedup.....a4cf6470570720a61f05ee7b75bab207 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14708736 01435221 |
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