Emergence of an early SARS-CoV-2 epidemic in the United States
| العنوان: | Emergence of an early SARS-CoV-2 epidemic in the United States |
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| المؤلفون: | Pedro Belda-Ferre, Karissa Chao, Vaughn S. Cooper, Gilberto Sabino-Santos, Gytis Dudas, Karthik Gangavarapu, Catelyn Anderson, Lauge Farnaes, Robert F. Garry, Rob Knight, Louise C. Laurent, Maximilian Marshall, Michelle McGraw, Lauren Gardner, David J. Nolan, Nathan D. Grubaugh, Raphaëlle Klitting, Jeremy P. Kamil, Stefan Aigner, Daniel J. Snyder, Arnaud Drouin, Rebecca Rose, Nathaniel L. Matteson, Antoinette R. Bell-Kareem, Manar Alkuzweny, Amy K. Feehan, Lilia I. Melnik, Refugio Robles-Sikisaka, Peter DeHoff, Sarah E. Topol, Allison R. Smither, Rona S. Scott, Clarisse Marotz, Kristian G. Andersen, Dahlene N. Fusco, Mark Zeller, Kamran Khan, Susanna L. Lamers, John A. Vanchiere, Gene W. Yeo, Emily G. Spencer, Laura Nicholson, Shashank Sathe, Phillipe Lemey, Emma B. Hodcroft, Marc A. Suchard, Julia Garcia-Diaz, Charlotte A. Hobbs, Laura D. Hughes, Kaylynn J. Genemaras, Alexander Watts, Patricia Snarski |
| المصدر: | medRxiv medRxiv, vol 2, iss 02-09 Cell, vol 184, iss 19 Cell |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 2019-20 coronavirus outbreak, Economic growth, Coronavirus disease 2019 (COVID-19), Genomic data, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Biology, genomic epidemiology, viral emergence, Medical and Health Sciences, General Biochemistry, Genetics and Molecular Biology, Article, law.invention, Disease Outbreaks, Vaccine Related, law, Risk Factors, Biodefense, Development economics, Humans, skin and connective tissue diseases, Epidemics, Viral Sequencing, Lung, Phylogeny, Travel, SARS-CoV-2, Prevention, fungi, Outbreak, COVID-19, viral sequencing, Biological Sciences, Louisiana, Texas, mobility, United States, phylogenetics, Transmission (mechanics), Geography, Good Health and Well Being, Emerging Infectious Diseases, Databases as Topic, Developmental Biology |
| الوصف: | The emergence of the COVID-19 epidemic in the United States (U.S.) went largely undetected due to inadequate testing. New Orleans experienced one of the earliest and fastest accelerating outbreaks, coinciding with Mardi Gras. To gain insight into the emergence of SARS-CoV-2 in the U.S. and how large-scale events accelerate transmission, we sequenced SARS-CoV-2 genomes during the first wave of the COVID-19 epidemic in Louisiana. We show that SARS-CoV-2 in Louisiana had limited diversity compared to other U.S. states, and that one introduction of SARS-CoV-2 led to almost all of the early transmission in Louisiana. By analyzing mobility and genomic data, we show that SARS-CoV-2 was already present in New Orleans before Mardi Gras, and the festival dramatically accelerated transmission. Our study provides an understanding of how superspreading during large-scale events played a key role during the early outbreak in the U.S. and can greatly accelerate epidemics. Genomic and epidemiological analyses provide a clearer picture of one of the earliest SARS-CoV-2 superspreader events in the United States in accelerating transmission, with a single introduction of the virus being responsible for most cases during this period. |
| وصف الملف: | application/pdf |
| تدمد: | 1097-4172 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a495fac7f184b16589de117d8afb0f20Test https://pubmed.ncbi.nlm.nih.gov/33564781Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a495fac7f184b16589de117d8afb0f20 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10974172 |
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