Insulin growth factor binding protein 7 is a novel target to treat dementia
| العنوان: | Insulin growth factor binding protein 7 is a novel target to treat dementia |
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| المؤلفون: | Ivana Delalle, Roberto Carlos Agis-Balboa, Hope Y Agbemenyah, Susanne Burkhardt, Andre Fischer |
| المصدر: | Neurobiology of disease 62, 135-143 (2014). doi:10.1016/j.nbd.2013.09.011 Neurobiology of Disease, Vol 62, Iss, Pp 135-143 (2014) |
| بيانات النشر: | Elsevier BV, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | IGFBP7, Regulator, Hippocampus, metabolism [Hippocampus], Mice, Transgenic, Insulin-like growth factor-binding protein, Learning and memory, lcsh:RC321-571, insulin-like growth factor binding protein-related protein 1, Mice, 03 medical and health sciences, drug effects [Memory], 0302 clinical medicine, Alzheimer Disease, Memory, ddc:570, drug effects [Behavior, Animal], medicine, Animals, Humans, Dementia, metabolism [Dementia], lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, 030304 developmental biology, genetics [Insulin-Like Growth Factor Binding Proteins], 0303 health sciences, Behavior, Animal, biology, DNA Methylation, medicine.disease, 3. Good health, Associative learning, Insulin-Like Growth Factor Binding Proteins, Mice, Inbred C57BL, Disease Models, Animal, Neurology, pharmacology [Insulin-Like Growth Factor Binding Proteins], metabolism [Insulin-Like Growth Factor Binding Proteins], Alzheimer, biology.protein, Epigenetics, Memory consolidation, Alzheimer's disease, Psychology, Neuroscience, metabolism [Alzheimer Disease], 030217 neurology & neurosurgery |
| الوصف: | Alzheimer's disease (AD) is the most common form of dementia in the elderly but effective therapeutic strategies to treat AD are not yet available. This is also due to the fact that the pathological mechanisms that drive the pathogenesis of sporadic AD are still not sufficiently understood and may differ on the individual level. Several risk factors such as altered insulin-like peptide (ILP) signaling have been linked to AD and modulating the ILP system has been discussed as a potential therapeutic avenue. Here we show that insulin-like growth factor binding protein 7 (IGFBP7), a protein that attenuates the function of ILPs, is up-regulated in the brains of AD patients and in a mouse model for AD via a process that involves altered DNA-methylation and coincides with decreased ILP signaling. Mimicking the AD-situation in wild type mice, by increasing hippocampal IGFBP7 levels leads to impaired memory consolidation. Consistently, inhibiting IGFBP7 function in mice that develop AD-like memory impairment reinstates associative learning behavior. These data suggest that IGFBP7 is a critical regulator of memory consolidation and might be used as a biomarker for AD. Targeting IGFBP7 could be a novel therapeutic avenue for the treatment of AD patients. |
| تدمد: | 0969-9961 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a426254e62e02e39de9d9f5455d843b1Test https://doi.org/10.1016/j.nbd.2013.09.011Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a426254e62e02e39de9d9f5455d843b1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09699961 |
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