Parametric response mapping on chest computed tomography associates with clinical and functional parameters in chronic obstructive pulmonary disease
| العنوان: | Parametric response mapping on chest computed tomography associates with clinical and functional parameters in chronic obstructive pulmonary disease |
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| المؤلفون: | Pim A. de Jong, Maarten van den Berge, Jan Willem J. Lammers, Leo Koenderman, Esther Pompe, Brian D. Ross, Craig J. Galbán, Firdaus A. A. Mohamed Hoesein, Dirkje S. Postma, Nick H. T. ten Hacken |
| المساهمون: | Lifestyle Medicine (LM), Groningen Research Institute for Asthma and COPD (GRIAC) |
| المصدر: | Respiratory Medicine, 123, 48. W.B. Saunders Ltd Respiratory Medicine, 123, 48-55. W B SAUNDERS CO LTD |
| بيانات النشر: | Elsevier BV, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Vital capacity, Pathology, viruses, Vital Capacity, Small airway disease, PROGRESSION, Severity of Illness Index, EXERCISE CAPACITY, Pulmonary function testing, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, FLOW LIMITATION, DLCO, Forced Expiratory Volume, Medicine, Lung volumes, 030212 general & internal medicine, Computed tomography, COPD, STATEMENT, Smoking, virus diseases, Middle Aged, humanities, Respiratory Function Tests, LUNG-FUNCTION, Parametric response mapping, Phenotypes, Phenotype, Pulmonary Emphysema, Cardiology, Female, medicine.symptom, SMOKERS, Adult, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Adolescent, Air trapping, Article, Young Adult, 03 medical and health sciences, FEV1/FVC ratio, FUTURE, Internal medicine, Image Interpretation, Computer-Assisted, Journal Article, Humans, Plethysmograph, Aged, Retrospective Studies, Emphysema, business.industry, medicine.disease, respiratory tract diseases, 030228 respiratory system, Copd, Tomography, X-Ray Computed, business |
| الوصف: | Background: In the search for specific phenotypes of chronic obstructive pulmonary disease (COPD) computed tomography (CT) derived Parametric Response Mapping (PRM) has been introduced. This study evaluates the association between PRM and currently available biomarkers of disease severity in COPD.Methods: Smokers with and without COPD were characterized based on questionnaires, pulmonary function tests, body plethysmography, and low-dose chest CT scanning. PRM was used to calculate the amount of emphysema (PRMEmph) and non-emphysematous air trapping (i.e. functional small airway disease, PRMfSAD). PRM was first compared with other biomarkers for emphysema (Perc15) and air trapping (E/I-ratio(MLD)). Consequently, linear regression models were utilized to study associations of PRM measurements with clinical parameters.Results: 166 participants were included with a mean +/- SD age of 50.5 +/- 17.7 years. Both PRMEmph and PRMfSAD were more strongly correlated with lung function parameters as compared to Perc15 and E/I-ratio(MLD). PRMEmph and PRMfSAD were higher in COPD participants than non-COPD participants (14.0% vs. 1.1%, and 31.6% vs. 8.2%, respectively, both p Conclusions: PRM strongly associates with the presence and severity of COPD. PRM therefore appears to be a valuable tool in differentiating COPD phenotypes. (C) 2016 Elsevier Ltd. All rights reserved. |
| وصف الملف: | image/pdf |
| تدمد: | 0954-6111 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3da5703a517ca2829c8fadfe2cf566eTest https://doi.org/10.1016/j.rmed.2016.11.021Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a3da5703a517ca2829c8fadfe2cf566e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09546111 |
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