Expression of VEGF and brain specific angiogenesis inhibitor-1 in glioblastoma: prognostic significance
| العنوان: | Expression of VEGF and brain specific angiogenesis inhibitor-1 in glioblastoma: prognostic significance |
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| المؤلفون: | Jong-Hyun Kim, Kwan Park, Do-Hyun Nam, Yeon-Lim Suh |
| المصدر: | Oncology Reports. |
| بيانات النشر: | Spandidos Publications, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Male, Vascular Endothelial Growth Factor A, Cancer Research, Pathology, medicine.medical_specialty, Gene Expression, Receptors, G-Protein-Coupled, Gene expression, Humans, Medicine, RNA, Messenger, Angiogenic Proteins, Brain-Specific Angiogenesis Inhibitor 1, Survival analysis, Aged, Oncogene, Brain Neoplasms, business.industry, Brain, Cancer, General Medicine, Middle Aged, Cell cycle, Prognosis, medicine.disease, Survival Analysis, Molecular medicine, Actins, Angiogenesis inhibitor, Oncology, Cancer research, Female, Glioblastoma, business |
| الوصف: | Brain specific angiogenesis inhibitor (BAI)-1 is a novel p53-inducible anti-angiogenic molecule. We examined the expression of BAI-1 in glial tumors and its association with patient survival. The expression of BAI-1 was evaluated in 20 brain tumors (meningiomas, pituitary adenomas, hemangiopericytomas, hemangioblastomas), 2 normal brain samples, 5 benign gliomas, and 26 glioblastomas. In the 26 glioblastoma tumors, we also evaluated the expression of VEGF, p53, p53 mutations, and MIB-1 to determine their association with survival. BAI-1 mRNA was expressed in all benign gliomas, normal brain, and 9 out of 26 glioblastomas, but not in the other tumors. Low VEGF and aberrant high expression of p53 were associated with a favorable outcome in univariate survival analysis, but they were not independent factors in multivariate analysis. For the treatment response, BAI-1 expression was associated with better response to radiation therapy (p=0.014). When we divided the patients into groups according to the expression patterns of BAI-1 and VEGF mRNA, the median survival of 9 patients with high VEGF expression and no expression of BAI-1 was just 6 months, while the median survival of the other 17 patients was 14 months (p=0.013). Glioblastomas with no BAI-1 and high VEGF mRNA expression are more often associated with poor clinical outcome. These findings suggest that the balance between the angiogenic and anti-angiogenic factors is important in the progression of glioblastoma and its response to treatment. |
| تدمد: | 1791-2431 1021-335X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3baf92c650a520f56021f8604487a2bTest https://doi.org/10.3892/or.11.4.863Test |
| رقم الانضمام: | edsair.doi.dedup.....a3baf92c650a520f56021f8604487a2b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17912431 1021335X |
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