Deep/mixed cerebral microbleeds are associated with cognitive dysfunction through thalamocortical connectivity disruption: The Taizhou Imaging Study
| العنوان: | Deep/mixed cerebral microbleeds are associated with cognitive dysfunction through thalamocortical connectivity disruption: The Taizhou Imaging Study |
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| المؤلفون: | Min Fan, Xingdong Chen, Weijun Tang, Yingzhe Wang, Kexun Zhang, Zhen Zhu, Li Jin, Kelin Xu, Shuyuan Li, Weizhong Tian, Mei Cui, Weimin Ye, Chen Suo, Qi Yang, Yanfeng Jiang, Qiang Dong, Ziyu Yuan |
| المصدر: | NeuroImage: Clinical, Vol 22, Iss, Pp-(2019) NeuroImage : Clinical |
| بيانات النشر: | Elsevier, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, WMH, white matter hyperintensity, GRE, gradient recalled echo, Neuropsychological Tests, lcsh:RC346-429, 0302 clinical medicine, Thalamus, BPF, brain parenchymal fraction, GLM, general linear model, TIV, total intracranial volume, FA, fractional anisotropy, ATR, anterior thalamic radiation, CMB, cerebral microbleed, Cerebral Cortex, MMSE, Mini-Mental Status Examination, 05 social sciences, Neuropsychology, Montreal Cognitive Assessment, Regular Article, Cognition, Middle Aged, Magnetic Resonance Imaging, White Matter, White matter microstructure, Cognitive impairment, Status examination, CSVD, cerebral small vessel disease, Neurology, MCI, mild cognitive impairment, FLAIR, fluid attenuated inversion recovery, Cardiology, TGV, total gray volume, lcsh:R858-859.7, Female, AD, Alzheimer's disease, Cerebral microbleeds, MoCA, Montreal Cognitive Assessment, China, medicine.medical_specialty, MRA, magnetic resonance angiography, Cognitive Neuroscience, TFCE, threshold-free cluster enhancement, Decreased thalamic volume, lcsh:Computer applications to medicine. Medical informatics, 050105 experimental psychology, 03 medical and health sciences, Multimodal imaging, Internal medicine, Fractional anisotropy, medicine, Humans, Cognitive Dysfunction, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, lcsh:Neurology. Diseases of the nervous system, Aged, Cerebral Hemorrhage, LAC, lacune, business.industry, Imaging study, TBSS, tract-based spatial statistics, Cross-Sectional Studies, SWI, susceptibility weighted imaging, DTI, diffusion tensor imaging, Neurology (clinical), CVD, coronary vascular disease, business, MRI, magnetic resonance imaging, 030217 neurology & neurosurgery |
| الوصف: | Background Cerebral microbleeds (CMBs) are considered to be risk factors for cognitive dysfunction. The specific pathology and clinical manifestations of CMBs are different based on their locations. We investigated the association between CMBs at different locations and cognitive dysfunction and explored the potential underlying pathways in a rural Han Chinese population. Methods We used baseline data from 562 community-dwelling adults (55–65 years old) in the Taizhou Imaging Study between 2013 and 2015. All individuals underwent multimodal brain magnetic resonance imaging (MRI) and 444 subjects completed neuropsychological tests: the Mini-Mental Status Examination and the Montreal Cognitive Assessment. Multinomial logistic regression was used to estimate the association between CMBs and cognitive dysfunction. The volume of brain regions and white matter microstructure were analyzed using Freesurfer and tract-based spatial statistics, respectively. Results CMBs were detected in 104 individuals (18.5%) in our study. Multinomial logistic regression found deep/mixed CMBs were associated with global cognitive dysfunction (OR 3.52; 95% CI 1.21 to 10.26), whereas lobar CMBs (OR 1.76; 95% CI 0.56 to 5.53) were not. Quantification of multimodal brain MRI showed that deep/mixed CMBs were accompanied by decreased thalamic volume and loss of fractional anisotropy of bilateral anterior thalamic radiations. Conclusion Deep/mixed CMBs were associated with cognitive dysfunction in this Chinese cross-sectional study. Disruption of thalamocortical connectivity might be a potential pathway underlying this relationship. Highlights • Cerebral microbleeds (CMBs) are found in 18.5% of middle-aged Chinese population. • Deep/mixed CMBs, not lobar CMBs, are associated with cognitive dysfunction. • Atrophy and fiber connectivity disruption might be the underlying neural pathways. |
| اللغة: | English |
| تدمد: | 2213-1582 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ab61fdd345fa2fbfe92fada8154f57Test http://www.sciencedirect.com/science/article/pii/S2213158219300993Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a3ab61fdd345fa2fbfe92fada8154f57 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22131582 |
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