Bosi, Emanuele, Boulware, David C., Becker, Dorothy J., Buckner, Jane H., Geyer, Susan, Gottlieb, Peter A., Henderson, Courtney, Kinderman, Amanda, Sosenko, Jay M., Steck, Andrea K., Bingley, Polly J.
المصدر:
2017, ' Impact of age and antibody type on progression from single to multiple autoantibodies in type 1 diabetes relatives ', Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 8, pp. 2881-2886 . https://doi.org/10.1210/jc.2017-00569Test
Context: Islet autoantibodies are markers of type 1 diabetes, and an increase in number of autoantibodies detected during the preclinical phase predicts progression to overt disease. Objective: To refine the effect of age in relation to islet antibody type on progression from single to multiple autoantibodies in relatives of people with type 1 diabetes. Research Design and Methods:Weexamined 994 relatives with normal glucose tolerance who were positive for a single autoantibody, followed prospectively in the TrialNet Pathway to Prevention. Antibodies to glutamic acid decarboxylase (GADA), insulin (IAA), insulinoma-associated antigen 2, and zinc transporter 8 and islet cell antibodies were tested every 6 to 12 months. The primary outcome was confirmed development of multiple autoantibodies. Age was categorized as
