Protein Arginine Methyltransferases in Cardiovascular and Neuronal Function
| العنوان: | Protein Arginine Methyltransferases in Cardiovascular and Neuronal Function |
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| المؤلفون: | Reggie Hui-Chao Lee, Har Lee E. Possoit, Celeste Yin-Chieh Wu, Chih Feng Lien, Alireza Minagar, Cristiane T. Citadin, Adam Frankel, Mychal S. Grames, Alexandre Couto e Silva, Garrett A. Clemons, Hung Wen Lin |
| المصدر: | Mol Neurobiol |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Protein-Arginine N-Methyltransferases, Methyltransferase, Arginine, DNA repair, Neuroscience (miscellaneous), Inflammation, Biology, Cardiovascular System, Methylation, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, medicine, Animals, Humans, Cell biology, 030104 developmental biology, Neurology, chemistry, Cardiovascular Diseases, medicine.symptom, Signal transduction, Asymmetric dimethylarginine, Protein Processing, Post-Translational, 030217 neurology & neurosurgery, Function (biology) |
| الوصف: | The methylation of arginine residues by protein arginine methyltransferases (PRMTs) is a type of post-translational modification which is important for numerous cellular processes, including mRNA splicing, DNA repair, signal transduction, protein interaction, and transport. PRMTs have been extensively associated with various pathologies, including cancer, inflammation, and immunity response. However, the role of PRMTs has not been well described in vascular and neurological function. Aberrant expression of PRMTs can alter its metabolic products, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA). Increased ADMA levels are recognized as an independent risk factor for cardiovascular disease and mortality. Recent studies have provided considerable advances in the development of small-molecule inhibitors of PRMTs to study their function under normal and pathological states. In this review, we aim to elucidate the particular roles of PRMTs in vascular and neuronal function as a potential target for cardiovascular and neurological diseases. |
| تدمد: | 1559-1182 0893-7648 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34a86591c6360a6ceb5dadde67cc866Test https://doi.org/10.1007/s12035-019-01850-zTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a34a86591c6360a6ceb5dadde67cc866 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15591182 08937648 |
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