Intended Bridging Therapy or Intravenous Thrombolysis Alone in Minor Stroke With Basilar Artery Occlusion
| العنوان: | Intended Bridging Therapy or Intravenous Thrombolysis Alone in Minor Stroke With Basilar Artery Occlusion |
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| المؤلفون: | Laurent Suissa, Philippe Niclot, Denis Sablot, Bertrand Lapergue, Gioia Mione, Aude Triquenot, Isabelle Girard-Buttaz, Nadia Laksiri, Cyril Dargazanli, Michael Obadia, Cécile Preterre, Aïcha Lyoubi, Igor Sibon, Pierre Seners, Séverine Debiais, Duc-Long Duong, Caroline Arquizan, Guillaume Turc, Jean-Claude Baron, Jérémie Papassin, C. Lamy, Hilde Hénon, Pierre Garnier, Claire Perrin, Michel Piotin, Jean-Louis Mas, Serge Bracard |
| المساهمون: | RANCHON, GUILLAUME, Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), FHU NeuroVasc [Site Sainte-Anne, Paris] (GHU-PPN), Centre Hospitalier Sainte Anne [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Fondation Ophtalmologique Adolphe de Rothschild [Paris], Centre Hospitalier Saint Jean de Perpignan, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Hospitalier René Dubos [Pontoise], MINOR-STROKE Collaborators: Claire Perrin, Caroline Arquizan, Chantal Lamy, Igor Sibon, Michael Obadia, Jérémie Papassin, Hilde Henon, Cécile Preterre, Laurent Suissa, Séverine Debiais, Aïcha Lyoubi, Pierre Garnier, Isabelle Girard-Buttaz, Bertrand Lapergue, Aude Triquenot, Duc-Long Duong, Nadia Laksiri, Gioia Mione, Jean-Louis Mas |
| المصدر: | Stroke Stroke, American Heart Association, 2021, 52 (2), pp.699-702. ⟨10.1161/STROKEAHA.120.030992⟩ |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Bridging (networking), [SDV]Life Sciences [q-bio], medicine.medical_treatment, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, medicine.artery, Internal medicine, Fibrinolysis, ischemic stroke, Basilar artery, medicine, Vertebrobasilar Insufficiency, Humans, basilar artery, Thrombolytic Therapy, Propensity Score, Aged, Retrospective Studies, Thrombectomy, Advanced and Specialized Nursing, Aged, 80 and over, business.industry, Basilar artery occlusion, Minor stroke, Thrombolysis, Middle Aged, Combined Modality Therapy, [SDV] Life Sciences [q-bio], Mechanical thrombectomy, Stroke, Treatment Outcome, Ischemic stroke, Cardiology, fibrinolysis, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery |
| الوصف: | Background and Purpose: Whether bridging therapy (intravenous thrombolysis [IVT] followed by mechanical thrombectomy) is superior to IVT alone in minor stroke with basilar artery occlusion remains uncertain. Methods: Multicentric retrospective observational study of consecutive minor stroke patients (National Institutes of Health Stroke Scale score ≤5) with basilar artery occlusion intended for IVT alone or bridging therapy. Propensity-score weighting was used to reduce baseline between-groups differences, and residual imbalance was addressed through adjusted logistic regression, with excellent outcome (3-month modified Rankin Scale score 0–1) as the dependent variable. Results: Fifty-seven patients were included (28 and 29 in the bridging therapy and IVT alone groups, respectively). Following propensity-score weighting, the distribution of baseline clinical and radiological variables was similar across the 2 patient groups, except age, posterior circulation Alberta Stroke Program Early CT Score, history of hypertension and smoking, and onset-to-IVT time. Compared with IVT alone, bridging therapy was associated with excellent outcome (adjusted odds ratio=3.37 [95% CI, 1.13–10.03]; P =0.03). No patient experienced symptomatic intracranial hemorrhage. Conclusions: Our results suggest that bridging therapy may be superior to IVT alone in minor stroke with basilar artery occlusion. |
| تدمد: | 1524-4628 0039-2499 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a209096b76364eeaeedb813c889f31f4Test https://pubmed.ncbi.nlm.nih.gov/33406868Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a209096b76364eeaeedb813c889f31f4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244628 00392499 |
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