MeCP2 and CTCF: enhancing the cross-talk of silencers
| العنوان: | MeCP2 and CTCF: enhancing the cross-talk of silencers |
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| المؤلفون: | Philippe T. Georgel, Juan Ausió |
| المصدر: | Biochemistry and Cell Biology. 95:593-608 |
| بيانات النشر: | Canadian Science Publishing, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Regulation of gene expression, Genetics, CCCTC-Binding Factor, biology, Methyl-CpG-Binding Protein 2, Cell Biology, Computational biology, Insulator (genetics), Biochemistry, MECP2, Chromatin, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Histone, CTCF, DNA methylation, biology.protein, Animals, Humans, Gene Silencing, Epigenetics, Molecular Biology, 030217 neurology & neurosurgery |
| الوصف: | This paper provides a brief introductory review of the most recent advances in our knowledge about the structural and functional aspects of two transcriptional regulators: MeCP2, a protein whose mutated forms are involved in Rett syndrome; and CTCF, a constitutive transcriptional insulator. This is followed by a description of the PTMs affecting these two proteins and an analysis of their known interacting partners. A special emphasis is placed on the recent studies connecting these two proteins, focusing on the still poorly understood potential structural and functional interactions between the two of them on the chromatin substrate. An overview is provided for some of the currently known genes that are dually regulated by these two proteins. Finally, a model is put forward to account for their possible involvement in their regulation of gene expression. |
| تدمد: | 1208-6002 0829-8211 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18bbae098a0472c0363b16eba5db9d9Test https://doi.org/10.1139/bcb-2017-0147Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a18bbae098a0472c0363b16eba5db9d9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 12086002 08298211 |
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