Emerging Role of Neuropilin-1 and Angiotensin-Converting Enzyme-2 in Renal Carcinoma-Associated COVID-19 Pathogenesis
| العنوان: | Emerging Role of Neuropilin-1 and Angiotensin-Converting Enzyme-2 in Renal Carcinoma-Associated COVID-19 Pathogenesis |
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| المؤلفون: | Golzar Hossain, Jamal Uddin, Sharmin Akter |
| المصدر: | Infectious Disease Reports, Vol 13, Iss 81, Pp 902-909 (2021) Infectious Disease Reports |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Kidney, business.industry, Brief Report, Cancer, ACE2, COVID-19, renal carcinoma, medicine.disease, KIRC, Pathogenesis, KIRP, Other systems of medicine, Infectious Diseases, medicine.anatomical_structure, Downregulation and upregulation, Angiotensin-converting enzyme 2, Neuropilin 1, Cancer research, medicine, NRP1, Receptor, business, hormones, hormone substitutes, and hormone antagonists, RZ201-999, Host factor |
| الوصف: | Neuropilin-1 (NRP1) is a recently identified glycoprotein that is an important host factor for SARS-CoV-2 infection. On the other hand, angiotensin-converting enzyme-2 (ACE2) acts as a receptor for SARS-CoV-2. Additionally, both NRP1 and ACE2 express in the kidney and are associated with various renal diseases, including renal carcinoma. Therefore, the expression profiles of NRP1 and ACE2 in kidney renal clear cell carcinoma (KIRC) and kidney renal papillary cell carcinoma (KIRP) patients from the various cancer databases were investigated along with their impact on patients’ survivability. In addition, coexpression analysis of genes involved in COVID-19, KIRC, and KIRP concerning NRP1 and ACE2 was performed. The results demonstrated that both t NRP1 and ACE2 expressions are upregulated in KIRC and KIRP compared to healthy conditions and are significantly correlated with the survivability rate of KIRC patients. A total of 128 COVID-19-associated genes are coexpressed, which are positively associated with NRP1 and ACE2 both in KIRC and KIRP. Therefore, it might be suggested that, along with the ACE2, high expression of the newly identified host factor NRP1 in renal carcinomas may play a vital role in the increased risk of SARS-CoV-2 infection and survivability of COVID-19 patients suffering from kidney cancers. The findings of this investigation will be helpful for further molecular studies and prevention and/or treatment strategies for COVID-19 patients associated with renal carcinomas. |
| اللغة: | English |
| تدمد: | 2036-7449 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a141d42879b2a77717e23eb2ac92786fTest https://www.mdpi.com/2036-7449/13/4/81Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a141d42879b2a77717e23eb2ac92786f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20367449 |
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