Contribution of Growth Hormone and IGF-I to Early Diabetic Nephropathy in Type 1 Diabetes
| العنوان: | Contribution of Growth Hormone and IGF-I to Early Diabetic Nephropathy in Type 1 Diabetes |
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| المؤلفون: | Maria G. Dekker, Margaret L. Lawson, Etienne Sochett, Elizabeth A Cummings, Denis Daneman |
| المصدر: | Diabetes. 47:1341-1346 |
| بيانات النشر: | American Diabetes Association, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Time Factors, Adolescent, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Urinary system, Nephropathy, Diabetic nephropathy, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Albuminuria, Humans, Diabetic Nephropathies, Insulin-Like Growth Factor I, Child, Type 1 diabetes, Human Growth Hormone, business.industry, Puberty, medicine.disease, Androgen, Diabetes Mellitus, Type 1, Endocrinology, Female, Microalbuminuria, business, Kidney disease |
| الوصف: | In children and adolescents with type 1 diabetes, we have reported an association between duration of puberty and the prevalence of nephromegaly and microalbuminuria (MA), which are early markers of diabetic nephropathy. Growth hormone (GH), IGF-I, testosterone, and prorenin are potential mediators of this effect. This study examined the relationship of these hormonal factors to kidney volume (KV) and MA in 155 subjects (78 males, age 13.2 ± 3.5 years [mean ± SD]) with similar diabetes duration (6.83 ± 1.6 years) but varying pubertal experience (0–10 years). KV (by ultrasound), plasma IGF-I, testosterone, prorenin, and NaLi countertransport, and urinary albumin, urinary GH, and urinary IGF-I from three 24-h collections were measured. Multiple regression analysis showed that BSA (P < 0.0001) and urinary IGF-I (P = 0.001) were significantly associated with KV. MA subjects (albumin excretion rate 15–200 μg/min) had higher urinary IGF-I (P = 0.005) and urinary GH (P = 0.05) compared with normoalbuminuric subjects. Only 9% of the variance in urinary IGF-I could be attributed to plasma IGF-I (r = 0.30, P < 0.0001). Testosterone and prorenin were not associated with MA, but they were associated with KV in univariate analyses. The strong association of urinary IGF-I with KV, a marker for glomerular hypertrophy, and of both urinary IGF-I and urinary GH with MA suggests a role for these growth factors in the development of human diabetic nephropathy. Together, these data support animal studies that have shown that renal GH and IGF-I may contribute significantly to the pathogenesis of early diabetic nephropathy. |
| تدمد: | 1939-327X 0012-1797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f38b8ab88e1da4402bf944277728d2Test https://doi.org/10.2337/diab.47.8.1341Test |
| رقم الانضمام: | edsair.doi.dedup.....a0f38b8ab88e1da4402bf944277728d2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
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