Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease
| العنوان: | Alterations in brain leptin signalling in spite of unchanged |
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| المؤلفون: | María J. Ramírez, Francisco J. Gil-Bea, Eric Westman, Wasim Khan, Paula Merino-Serrais, Silvia Maioli, Farshad Falahati, Roberto Rimondini, Maria Lodeiro, Angel Cedazo-Minguez, Elena Puerta, Andrew Simmons, Alina Codita |
| المساهمون: | Silvia Maioli, Maria Lodeiro, Paula Merino-Serrai, Farshad Falahati, Wasim Khan, Elena Puerta, Alina Codita, Roberto Rimondini, Maria J. Ramirez, Andrew Simmon, Francisco Gil-Bea, Eric Westman, Angel Cedazo-Minguez |
| المصدر: | Dadun. Depósito Académico Digital de la Universidad de Navarra instname Aging Cell |
| بيانات النشر: | Wiley, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Leptin, Aging, medicine.medical_specialty, Amyloid beta, Apolipoprotein E4, Hippocampus, Mice, Transgenic, Neuroimaging, CSF, Chromosomal translocation, Disease, Cohort Studies, Alzheimer Disease, Internal medicine, mental disorders, medicine, Animals, Humans, leptin receptor, Leptin receptors, Aged, ApoE genotype, Leptin receptor, biology, digestive, oral, and skin physiology, Brain, Original Articles, Organ Size, Cell Biology, medicine.disease, amyloid-beta, Mice, Inbred C57BL, Endocrinology, nervous system, Linear Models, biology.protein, leptin receptors, Receptors, Leptin, Female, Amyloid-beta, Alzheimer's disease, Signal transduction, Alzheimer’s disease, Biomarkers, hormones, hormone substitutes, and hormone antagonists, Signal Transduction |
| الوصف: | Several studies support the relation between leptin and Alzheimer’s disease (AD). We show that leptin levels in CSF are unchanged as subjects progress to AD. However, in AD hippocampus, leptin signalling was decreased and leptin localization was shifted, being more abundant in reactive astrocytes and less in neurons. Similar translocation of leptin was found in brains from Tg2576 and apoE4 mice. Moreover, an enhancement of leptin receptors was found in hippocampus of young Tg2576 mice and in primary astrocytes and neurons treated with Ab1-42. In contrast, old Tg2576 mice showed decreased leptin receptors levels. Similar findings to those seen in Tg2576 mice were found in apoE4, but not in apoE3 mice. These results suggest that leptin levels are intact, but leptin signalling is impaired in AD. Thus, Ab accumulation and apoE4 genotype result in a transient enhancement of leptin signalling that might lead to a leptin resistance state over time. |
| وصف الملف: | application/pdf; STAMPA |
| تدمد: | 1474-9726 1474-9718 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05dc30deec2b77f48a04d5a3dc1831eTest https://doi.org/10.1111/acel.12281Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a05dc30deec2b77f48a04d5a3dc1831e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14749726 14749718 |
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