Maternal PUFA ω-3 Supplementation Prevents Neonatal Lung Injuries Induced by Hyperoxia in Newborn Rats
| العنوان: | Maternal PUFA ω-3 Supplementation Prevents Neonatal Lung Injuries Induced by Hyperoxia in Newborn Rats |
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| المؤلفون: | Ali Houeijeh, Estelle Aubry, Dyuti Sharma, Armande Subayi Nkembi, Laura Butruille, Véronique Houfflin-Debarge, Laurent Storme, Rémi Besson, Philippe Deruelle |
| المصدر: | International Journal of Molecular Sciences, Vol 16, Iss 9, Pp 22081-22093 (2015) International Journal of Molecular Sciences Volume 16 Issue 9 Pages 22081-22093 |
| بيانات النشر: | MDPI AG, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Pediatrics, lcsh:Chemistry, Pregnancy, Lactation, Lung, Prenatal Nutritional Physiological Phenomena, lcsh:QH301-705.5, Spectroscopy, Hyperoxia, chemistry.chemical_classification, food and beverages, General Medicine, respiratory system, Computer Science Applications, medicine.anatomical_structure, Gestation, Female, lipids (amino acids, peptides, and proteins), medicine.symptom, PUFA ω-3, Polyunsaturated fatty acid, medicine.medical_specialty, Catalysis, Article, Inorganic Chemistry, Internal medicine, Fatty Acids, Omega-3, bronchopulmonary dysplasia, medicine, Animals, Physical and Theoretical Chemistry, Rats, Wistar, Molecular Biology, business.industry, Organic Chemistry, prematurity, medicine.disease, eye diseases, Rats, Low birth weight, Endocrinology, chemistry, Bronchopulmonary dysplasia, lcsh:Biology (General), lcsh:QD1-999, Dietary Supplements, business, diet |
| الوصف: | Bronchopulmonary dysplasia (BPD) is one of the most common complications of prematurity, occurring in 30% of very low birth weight infants. The benefits of dietary intake of polyunsaturated fatty acids ω-3 (PUFA ω-3) during pregnancy or the perinatal period have been reported. The aim of this study was to assess the effects of maternal PUFA ω-3 supplementation on lung injuries in newborn rats exposed to prolonged hyperoxia. Pregnant female Wistar rats (n = 14) were fed a control diet (n = 2), a PUFA ω-6 diet (n = 6), or a PUFA ω-3 diet (n = 6), starting with the 14th gestation day. At Day 1, female and newborn rats (10 per female) were exposed to hyperoxia (O2, n = 70) or to the ambient air (Air, n = 70). Six groups of newborns rats were obtained: PUFA ω-6/O2 (n = 30), PUFA ω-6/air (n = 30), PUFA ω-3/O2 (n = 30), PUFA ω-3/air (n = 30), control/O2 (n = 10), and control/air (n = 10). After 10 days, lungs were removed for analysis of alveolarization and pulmonary vascular development. Survival rate was 100%. Hyperoxia reduced alveolarization and increased pulmonary vascular wall thickness in both control (n = 20) and PUFA ω-6 groups (n = 60). Maternal PUFA ω-3 supplementation prevented the decrease in alveolarization caused by hyperoxia (n = 30) compared to PUFA ω-6/O2 (n = 30) or to the control/O2 (n = 10), but did not significantly increase the thickness of the lung vascular wall. Therefore, maternal PUFA ω-3 supplementation may protect newborn rats from lung injuries induced by hyperoxia. In clinical settings, maternal PUFA ω-3 supplementation during pregnancy and during lactation may prevent BPD development after premature birth. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff0c898e390da148fba78f3f2b22caaTest http://www.mdpi.com/1422-0067/16/9/22081Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9ff0c898e390da148fba78f3f2b22caa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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