Toward the understanding of the role of CDC48, a major component of the protein quality control, in plant immunity
| العنوان: | Toward the understanding of the role of CDC48, a major component of the protein quality control, in plant immunity |
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| المؤلفون: | Hervé Bègue, Claire Rosnoblet, David Wendehenne, Arnaud Mounier |
| المساهمون: | Agroécologie [Dijon], Université de Bourgogne (UB)-Institut National de la Recherche Agronomique (INRA)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Centre National de la Recherche Scientifique (CNRS), French 'Investissements d'Avenir' program, project ISITE-BFC [ANR-15-IDEX-0003, NOISELESS -RA18041.AEC.IS], 'Region Bourgogne Franche-Comte Region', Envergure project RHINO [2018Y -07113], Agence Nationale de la Recherche [ANR-18-CE20-0022-02], French Ministry of Higher Education, Research and Innovation |
| المصدر: | Plant Science Plant Science, Elsevier, 2019, 279, pp.34-44. ⟨10.1016/j.plantsci.2018.10.029⟩ |
| بيانات النشر: | HAL CCSD, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0106 biological sciences, 0301 basic medicine, Proteasome Endopeptidase Complex, Interactome, [SDV]Life Sciences [q-bio], Plant Immunity, Plant Science, Endoplasmic-reticulum-associated protein degradation, Biology, Protein degradation, 01 natural sciences, 03 medical and health sciences, Immune system, Plant immunity, Valosin Containing Protein, Genetics, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, S-adenosyl-methionine, Plant Proteins, CDC48, Endoplasmic reticulum, General Medicine, Plants, Cell biology, 030104 developmental biology, Proteasome, Ubiquitin-proteasome system, [SDE]Environmental Sciences, Agronomy and Crop Science, Protein quality, 010606 plant biology & botany |
| الوصف: | International audience; The evolutionally conserved chaperone-like protein CDC48 (cell division cycle 48) is a major component of ubiquitin-dependent protein degradation pathways in animal and yeast and, more generally, of the protein quality control machinery. In plants, CDC48 plays essential regulatory functions in development and the possibly that it contributes to protein degradation through the ubiquitin-proteasome system (UPS) and the endoplasmic reticulum-associated protein degradation (ERAD) system has been reported. In this review we described recent findings highlighting a role for CDC48 in plant immunity. First data indicated that CDC48 is S-nitrosylated in plant cells undergoing an immune response, regulates the turnover of immune receptors and mediates the degradation of viral proteins. Furthermore its overexpression was associated to an exacerbated hypersensitive-like cell death. We also designed and reported here the first CDC48 interactome. The corresponding data confirm the closed interaction of CDC48 with components of the UPS and shed light on its putative regulatory function of S-adenosyl-methionine synthesis and metabolism. More generally, these investigations further support the concept that plant cells facing pathogen attack finely regulate the protein quality control machinery. |
| اللغة: | English |
| تدمد: | 0168-9452 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe650388eade66effbe8626d91d0fdaTest https://hal.inrae.fr/hal-02626427/file/S0168945218309117.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9fe650388eade66effbe8626d91d0fda |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01689452 |
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