NovelChlamydia trachomatisStrains in Heterosexual Sex Partners, Indianapolis, Indiana, USA
| العنوان: | NovelChlamydia trachomatisStrains in Heterosexual Sex Partners, Indianapolis, Indiana, USA |
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| المؤلفون: | James A. Williams, Linda He, Deborah Dean, J. Dennis Fortenberry, Byron E. Batteiger, Raymond Wan, Arissa Ma |
| المصدر: | Emerging Infectious Diseases |
| بيانات النشر: | Centers for Disease Control and Prevention (CDC), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, Microbiology (medical), Indiana, Adolescent, Genotype, Epidemiology, Chlamydia trachomatis, Biology, medicine.disease_cause, STIs, partner tracing, Young Adult, Phylogenetics, recombinant strains, medicine, Humans, Typing, heterosexual partners, Heterosexuality, bacteria, Phylogeny, sexually transmitted infections, USA, Recombination, Genetic, Genetics, Novel Chlamydia trachomatis Strains in Heterosexual Sex Partners, Indianapolis, Indiana, USA, Phylogenetic tree, Research, Strain (biology), Sex partners, Chlamydia Infections, Virology, 3. Good health, Sexual Partners, Infectious Diseases, Genes, Bacterial, Multilocus sequence typing, Female, Multilocus Sequence Typing, MLST |
| الوصف: | Use of multilocus sequence typing may help identify new strains in at-risk populations. Chlamydia trachomatis causes a high number of sexually transmitted infections worldwide, but reproducible and precise strain typing to link partners is lacking. We evaluated multilocus sequence typing (MLST) for this purpose by detecting sequence types (STs) concordant for the ompA genotype, a single-locus typing standard. We tested samples collected during April 2000–October 2003 from members of established heterosexual partnerships (dyads) in the Indianapolis, Indiana, USA, area who self-reported being coital partners within the previous 30 days. C. trachomatis DNA from 28 dyads was tested by MLST; sequences were aligned and analyzed for ST and phylogenetic relationships. MLST detected 9 C. trachomatis STs, 4 unique to Indianapolis; STs were identical within each dyad. Thirteen unique strains were identified; 9 (32%) dyads harbored novel recombinant strains that phylogenetically clustered with strains comprising the recombinants. The high rate of novel C. trachomatis recombinants identified supports the use of MLST for transmission and strain diversity studies among at-risk populations. |
| تدمد: | 1080-6059 1080-6040 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb99dc0c00508ae5b45cf2a4f78bfd3Test https://doi.org/10.3201/2011.140604Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9fb99dc0c00508ae5b45cf2a4f78bfd3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10806059 10806040 |
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