Long‐term efficacy and safety of dichlorphenamide for treatment of primary periodic paralysis
| العنوان: | Long‐term efficacy and safety of dichlorphenamide for treatment of primary periodic paralysis |
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| المؤلفون: | Valeria A. Sansone, Jeffrey Statland, Nicholas E. Johnson, Michael G. Hanna, Emma Ciafaloni, Fredric Cohen, Perry B Shieh, Robert C. Griggs |
| المصدر: | Muscle & Nerve. 64:342-346 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Dichlorphenamide, Physiology, Placebo, Gastroenterology, Paralyses, Familial Periodic, Young Adult, Cellular and Molecular Neuroscience, Double-Blind Method, Physiology (medical), Internal medicine, Post-hoc analysis, medicine, Paralysis, Humans, Carbonic Anhydrase Inhibitors, Adverse effect, Aged, business.industry, Periodic paralysis, Middle Aged, medicine.disease, Discontinuation, Treatment Outcome, Tolerability, Female, Neurology (clinical), medicine.symptom, business |
| الوصف: | INTRODUCTION/AIM Long-term efficacy and safety of dichlorphenamide (DCP) were characterized in patients with primary periodic paralysis (PPP). METHODS Patients with PPP in a double-blind, placebo-controlled study were randomly assigned to receive DCP 50 mg twice daily or placebo for 9 weeks, followed by a 52-week open-label DCP treatment phase (DCP/DCP and placebo/DCP populations). Efficacy (attack rate, severity-weighted attack rate) and safety were assessed in patients completing the study (61 weeks). In this post hoc analysis, efficacy and safety data were pooled from hyperkalemic and hypokalemic substudies. RESULTS Sixty-three adults (age, 19-76 years) completed the double-blind phase; 47 (74.6%) of these patients completed 61 weeks. There were median decreases in weekly attack and severity-weighted attack rates from baseline to week 61 (DCP/DCP [n = 25], -1.00 [P |
| تدمد: | 1097-4598 0148-639X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa010f2a4628a0d1c664cee4191269bTest https://doi.org/10.1002/mus.27354Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9fa010f2a4628a0d1c664cee4191269b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10974598 0148639X |
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