Re‐evaluating diagnostic thresholds for intrahepatic cholestasis of pregnancy: case–control and cohort study
| العنوان: | Re‐evaluating diagnostic thresholds for intrahepatic cholestasis of pregnancy: case–control and cohort study |
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| المؤلفون: | Kypros H. Nicolaides, Caroline Ovadia, Joanna Girling, Marcus Martineau, Catherine Williamson, Argyro Syngelaki, Paul T. Seed, Tharni Vasavan, K. Souretis, Hei Man Fan, Alice Mitchell, John C. Chambers, Jrf Walters |
| المصدر: | BJOG: An International Journal of Obstetrics & Gynaecology. 128:1635-1644 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Population, Reference range, Cholestasis, Intrahepatic, Sensitivity and Specificity, Gastroenterology, Bile Acids and Salts, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Cholestasis, Pregnancy, Prenatal Diagnosis, Internal medicine, Humans, Medicine, 030212 general & internal medicine, education, Retrospective Studies, education.field_of_study, 030219 obstetrics & reproductive medicine, business.industry, musculoskeletal, neural, and ocular physiology, Obstetrics and Gynecology, Retrospective cohort study, medicine.disease, Confidence interval, 3. Good health, Pregnancy Complications, Postprandial, Case-Control Studies, Female, business, Biomarkers, Cholestasis of pregnancy |
| الوصف: | OBJECTIVE To determine the optimal total serum bile acid (TSBA) threshold and sampling time for accurate intrahepatic cholestasis of pregnancy (ICP) diagnosis. DESIGN Case-control, retrospective cohort studies. SETTING Antenatal clinics, clinical research facilities. POPULATION Women with ICP or uncomplicated pregnancies. METHODS Serial TSBA measurements were performed pre-/postprandially in 42 women with ICP or uncomplicated pregnancy. Third-trimester non-fasting TSBA reference ranges were calculated from 561 women of black, south Asian and white ethnicity. Rates of adverse perinatal outcomes for women with ICP but peak non-fasting TSBA below the upper reference range limit were compared with those in healthy populations. MAIN OUTCOME MEASURES Sensitivity and specificity of common TSBA thresholds for ICP diagnosis, using fasting and postprandial TSBA. Calculation of normal reference ranges of non-fasting TSBA. RESULTS Concentrations of TSBA increased markedly postprandially in all groups, with overlap between healthy pregnancy and mild ICP (TSBA |
| تدمد: | 1471-0528 1470-0328 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9ac8ab3e8fc6a0b8941a70bd78580aTest https://doi.org/10.1111/1471-0528.16669Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9f9ac8ab3e8fc6a0b8941a70bd78580a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14710528 14700328 |
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