Antibody to the Human T-Lymphotropic Virus Type 1 (HTLV-1) Envelope Protein Gp46 in Patients Co-infected with HCV and HTLV-1
| العنوان: | Antibody to the Human T-Lymphotropic Virus Type 1 (HTLV-1) Envelope Protein Gp46 in Patients Co-infected with HCV and HTLV-1 |
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| المؤلفون: | Norihiro Furusyo, Masayuki Murata, Yasuko Sagara, Jun Hayashi, Hiroaki Takeoka, Kazuhiro Toyoda, Seizaburo Kashiwagi |
| المصدر: | The American Journal of Tropical Medicine and Hygiene. 77:192-196 |
| بيانات النشر: | American Society of Tropical Medicine and Hygiene, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, Cirrhosis, Hepacivirus, Hepatitis C virus, Retroviridae Proteins, Oncogenic, Enzyme-Linked Immunosorbent Assay, Chronic liver disease, medicine.disease_cause, Liver disease, Japan, Virology, Prevalence, Humans, Medicine, Aged, Aged, 80 and over, Human T-lymphotropic virus 1, biology, business.industry, Gene Products, env, Hepatitis C, Middle Aged, medicine.disease, biology.organism_classification, HTLV-I Infections, HTLV-I Antibodies, Infectious Diseases, Hepatocellular carcinoma, Immunology, Female, Parasitology, HTLV-I Antigens, business |
| الوصف: | Human T-lymphotropic virus type 1 (HTLV-1) infection is known to affect hepatitis C virus (HCV) clearance and to accelerate the development of hepatocellular carcinoma in HCV-infected patients. In this study, we found the prevalence and titer of an antibody recognizing the central region of the HTLV-1 Gp46 protein to be associated with the severity of chronic liver disease. The antibody prevalence was significantly correlated with the stage of chronic liver disease (P < 0.0001): 3 (14.3%) of 21 patients with minimal-mild chronic hepatitis, 12 (24%) of 50 with moderate-severe chronic hepatitis, 7 (87.5%) of 8 with liver cirrhosis, and 13 (100%) of 13 with hepatocellular carcinoma. These results indicate that the antibody may be a useful marker of the deterioration of liver disease in patients co-infected with HCV and HTLV-1. This antibody may be useful for the diagnosis of liver diseases and the development of more effective treatments. |
| تدمد: | 1476-1645 0002-9637 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e188b86feb2eadede05f67c49dd6ab1Test https://doi.org/10.4269/ajtmh.2007.77.192Test |
| رقم الانضمام: | edsair.doi.dedup.....9e188b86feb2eadede05f67c49dd6ab1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14761645 00029637 |
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