Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways
| العنوان: | Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways |
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| المؤلفون: | Ji Miao, Sudha B. Biddinger, Ivana Semova, Anthony N. Hollenberg, Hong Kang, Matthew D. Hirschey, David Masson, Yue Hu, Satyapal Chahar, Xiaowei Sun |
| المساهمون: | Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Harvard Medical School [Boston] ( HMS ), Beth Israel Deaconess Medical Center, Lipides - Nutrition - Cancer [Dijon - U1231] ( LNC ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Duke University Medical Center |
| المصدر: | Journal of Biological Chemistry Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2018, 293 (6), pp.2006-2014. 〈http://www.jbc.org/content/293/6/2006.longTest〉. 〈10.1074/jbc.M117.782557〉 |
| بيانات النشر: | HAL CCSD, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, medicine.medical_specialty, mTORC1, Mechanistic Target of Rapamycin Complex 1, Biochemistry, metabolic syndrome, fructose, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Internal medicine, Gene expression, medicine, Animals, glucose, Molecular Biology, [ SDV.BBM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Triglycerides, lipogenesis, Mice, Knockout, Fatty liver, dyslipidemia, mammalian target of rapamycin (mTOR), Lipid metabolism, Fructose, Cell Biology, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Metabolism, chemistry, Gene Expression Regulation, Liver, Lipogenesis, Metabolic syndrome, Signal transduction, biological phenomena, cell phenomena, and immunity, 030217 neurology & neurosurgery, Signal Transduction |
| الوصف: | International audience; Although calorically equivalent to glucose, fructose appears to be more lipogenic, promoting dyslipidemia, fatty liver disease, cardiovascular disease, and diabetes. To better understand how fructose induces lipogenesis, we compared the effects of fructose and glucose on mammalian target of rapamycin complex 1 (mTORC1), which appeared to have both positive and negative effects on lipogenic gene expression. We found that fructose acutely and transiently suppressed mTORC1 signalingin vitroandin vivoThe constitutive activation of mTORC1 reduced hepatic lipogenic gene expression and produced hypotriglyceridemia after 1 week of fructose feeding. In contrast, glucose did not suppress mTORC1, and the constitutive activation of mTORC1 failed to suppress plasma triglycerides after 1 week of glucose feeding. Thus, these data reveal fundamental differences in the signaling pathways used by fructose and glucose to regulate lipid metabolism. |
| اللغة: | English |
| تدمد: | 0021-9258 1083-351X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0151552b633fb1a9d27448adf7dd3bTest https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01730773Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9e0151552b633fb1a9d27448adf7dd3b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00219258 1083351X |
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